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      Evaluation of the malignancy of glioma using 11C-methionine positron emission tomography and proliferating cell nuclear antigen staining.

      Neurosurgical Review
      Adult, Aged, Brain Neoplasms, diagnosis, metabolism, radionuclide imaging, Carbon Radioisotopes, diagnostic use, Female, Glioma, Humans, Magnetic Resonance Imaging, Male, Methionine, Middle Aged, Proliferating Cell Nuclear Antigen, Staining and Labeling, Tomography, Emission-Computed

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          Abstract

          11C-methionine positron emission tomography (PET) and proliferating cell nuclear antigen (PCNA) staining were performed in 13 cases of glioma to investigate the relationship between the uptake of L-[methyl]-11C-methionine and the degree of malignancy and proliferative potential. The 11C-methionine uptake was significantly greater in high-grade gliomas compared to low-grade gliomas (P<0.05). The PCNA indexes were also significantly higher in the high-grade cases (P<0.05). Moreover, a strong positive correlation was found between the 11C-methionine values and the PCNA indexes (P<0.005), demonstrating that higher 11C-methionine uptake was associated with greater proliferative potential and greater malignancy. 11C-methionine PET is a potentially useful preoperative method to discriminate the malignancy of glioma.

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