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      Tissue Uptake and Distribution of 3H-Dexamethasone in Early Myocardial Ischemia 1

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          Abstract

          The tissue uptake and distribution of <sup>3</sup>H-dexamethasone were studied in anesthetized cats subjected to acute myocardial ischemia. 1 h after injection of <sup>3</sup>H-dexamethasone, liver, kidney, intestine, pancreas and heart exhibited tissue/plasma ratios between 2 and 7. Adrenal, spleen and lung tissue exhibited T/P ratios from 1 to 2, while ratios less than 1 were found in abdominal aorta, skeletal muscle and omentum. Although uptake of dexamethasone was decreased in the ischemic myocardium as compared with the non-ischemic myocardium, the ischemic region took up 78% of that taken up by normal myocardium. Pancreatic tissue accumulated significantly greater quantities of <sup>3</sup>H-dexamethasone in cats subjected to myocardial ischemia than in sham-operated controls. <sup>3</sup>H-dexamethasone did not undergo significant metabolism by the heart in the first 2 h following coronary occlusion or after an equivalent sham operation. These data are consistent with a rapid uptake mechanism of glucocorticoid by myocardial tissue. The data also indicate that the large amounts of exogenously administered glucocorticoid remain essentially intact in the heart during the first 2 h of the ischemic process.

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          Author and article information

          Journal
          CRD
          Cardiology
          10.1159/issn.0008-6312
          Cardiology
          S. Karger AG
          0008-6312
          1421-9751
          1976
          1976
          29 October 2008
          : 61
          : 5-6
          : 341-352
          Affiliations
          Department of Physiology, Jefferson Medical College, Thomas Jefferson University Philadelphia, Pa.
          Article
          169780 Cardiology 1976;61:341–352
          10.1159/000169780
          © 1976 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 12
          Categories
          Original Paper

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