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      Ineffective endovascular treatment of a giant internal carotid artery aneurysm

      case-report

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          Abstract

          Purpose

          Despite a growing range of therapeutic possibilities, including various intravascular methods, treating cerebral aneurysms can be still a therapeutic challenge. A growing number of patients previously treated with older techniques require additional therapy. Treatment options as well as their efficiency may be influenced by previous procedures.

          Case report

          We report a rare case of a giant treatment-resistant aneurysm in a 65-year-old woman. The aneurysm was first diagnosed due to visual disturbances in the right eye. Computed tomography angiography showed large (20 × 18 mm) wide neck aneurysm of the right internal carotid artery. The patient was subsequently treated with several methods including coiling with regular stent implantation, two flow diverter stent implantations, and hybrid neurosurgery. Full occlusion was not achieved after any of those procedures. After the last procedure (hybrid neurosurgery) the patient, in vegetative state, was transferred to the intensive care unit and then to the Health and Care Centre.

          Conclusions

          Discussion focuses on endovascular treatment options after failure of previous treatment such as “stent in stent” technique. We conclude that three subsequent stent implantations are technically possible; however, subsequent procedures are associated with technical difficulties and their effectiveness is questionable. Ventriculoperitoneal shunt may influence the outcome of flow diversion therapy.

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          Most cited references12

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          An overview of intracranial aneurysms

          Intracranial aneurysms are relatively common, with a prevalence of approximately 4%. Unruptured aneurysms may cause symptoms mainly due to a mass effect, but the real danger is when an aneurysm ruptures, leading to a subarachnoid hemorrhage. Most aneurysms are asymptomatic and will not rupture, but they grow unpredictably and even small aneurysms carry a risk of rupture. Intracranial aneurysms are diagnosed and monitored with imaging including intra-arterial digital subtraction angiography, computed tomography angiography, magnetic resonance angiography, and recently transcranial Doppler ultrasonograpy has been proposed as a potential modality. Treatment options include observation, endovascular coiling, and surgical clipping. This paper will review the epidemiology, pathogenesis, clinical presentation, diagnosis, natural history, and management of unruptured saccular intracranial aneurysms.
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            Learning from failure: persistence of aneurysms following pipeline embolization

            A detailed analysis was performed of anterior circulation aneurysms treated with a Pipeline Embolization Device (PED) that did not progress to complete occlusion by 1-year follow-up. Angiography was performed with the purpose of identifying specific factors potentially responsible for these failed outcomes. From among the first 100 patients with anterior circulation aneurysms, 92 underwent 1-year follow-up angiography and were individually studied through review of their pre- and postembolization studies. Nineteen aneurysms (21%) remained unoccluded at 12 months. Independent predictors of treatment failure, identified by logistic regression analysis, were found to be fusiform aneurysm morphology, decreasing dome-to-neck ratio, and the presence of a preexisting laser-cut stent. Further examination of individual cases identified several common mechanisms—device malapposition, inadequate coverage of the aneurysm neck with persistent exchange across the device, and the incorporation of a branch vessel into the aneurysm fundus—potentially contributing to failed treatment in these settings. Attention to specific features of the aneurysm and device construct can frequently identify cases predisposed to treatment failure and suggest strategies to maximize favorable outcomes.
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              Successful endovascular treatment of a growing megadolichoectasic vertebrobasilar artery aneurysm by flow diversion using the "diverter-in-stent" technique.

              Giant dolichoectatic and fusiform aneurysms of the vertebrobasilar artery are among the most difficult and dangerous aneurysms to treat. Conservative management may be reasonable in asymptomatic elderly patients. Nevertheless, due to the frequent presence of mass effect on the brainstem and the risks of thromboembolic events and rupture, these aneurysms often demand treatment rather than observation. With the advancement of endovascular techniques some of these lesions have become treatable without the high morbidity and mortality rates associated with open surgical treatment. When dealing with giant, progressively enlarging symptomatic aneurysms, more limited therapeutic alternatives are available. The authors present a case of a growing megadolichoectatic vertebrobasilar artery aneurysm causing major disability due to increasing mass effect in a 51-year-old man. The aneurysm was treated with flow diversion by placing multiple telescoped stents and diverters ("diverter-in-stent" technique), achieving thrombosis of the aneurysm and reduction of the mass effect on the brainstem, with neurological improvement. The successful clinical and angiographic results observed in our case of giant dolichoectasic vertebrobasilar aneurysm contribute to the literature on giant aneurysms treated by means of flow diversion.
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                Author and article information

                Journal
                Pol J Radiol
                Pol J Radiol
                PJR
                Polish Journal of Radiology
                Termedia Publishing House
                1733-134X
                1899-0967
                27 June 2020
                2020
                : 85
                : e323-e327
                Affiliations
                [1 ]Chair of Radiology, Jagiellonian University Medical College, Krakow, Poland
                [2 ]Students’ Scientific Group at the Chair of Radiology, Jagiellonian University Medical College, Krakow, Poland
                [3 ]Department of Neurosurgery, Jagiellonian University Medical College, Krakow, Poland
                [4 ]Department of Imaging Studies, Emergency and Mass-Event Medicine Trauma Centre, University Hospital, Krakow, Poland
                Author notes
                Correspondence address: Ositadima Chukwu, Students’ Scientific Group at the Chair of Radiology, Jagiellonian University Medical College, 19 Kopernika St., 31-501 Krakow, Poland, e-mail: stdmchkw@ 123456gmail.com
                [A]

                Study design

                [B]

                Data collection

                [C]

                Statistical analysis

                [D]

                Data interpretation

                [E]

                Manuscript preparation

                [F]

                Literature search

                [G]

                Funds collection

                Article
                41191
                10.5114/pjr.2020.96979
                7361365
                ce8df727-60a3-45db-83f5-2e786f8f1201
                Copyright © Polish Medical Society of Radiology 2020

                This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial-No Derivatives 4.0 International (CC BY-NC-ND 4.0). License ( https://creativecommons.org/licenses/by-nc-nd/4.0/)

                History
                : 17 February 2020
                : 14 April 2020
                Categories
                Case Report

                Radiology & Imaging
                endovascular treatment,flow diverter,stent-in-stent technique,intracranial aneurysm

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