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      Hibiscus sabdariffa L. - a phytochemical and pharmacological review.

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          Abstract

          Hibiscus sabdariffa L. (Hs, roselle; Malvaceae) has been used traditionally as a food, in herbal drinks, in hot and cold beverages, as a flavouring agent in the food industry and as a herbal medicine. In vitro and in vivo studies as well as some clinical trials provide some evidence mostly for phytochemically poorly characterised Hs extracts. Extracts showed antibacterial, anti-oxidant, nephro- and hepato-protective, renal/diuretic effect, effects on lipid metabolism (anti-cholesterol), anti-diabetic and anti-hypertensive effects among others. This might be linked to strong antioxidant activities, inhibition of α-glucosidase and α-amylase, inhibition of angiotensin-converting enzymes (ACE), and direct vaso-relaxant effect or calcium channel modulation. Phenolic acids (esp. protocatechuic acid), organic acid (hydroxycitric acid and hibiscus acid) and anthocyanins (delphinidin-3-sambubioside and cyanidin-3-sambubioside) are likely to contribute to the reported effects. More well designed controlled clinical trials are needed which use phytochemically characterised preparations. Hs has an excellent safety and tolerability record.

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          Author and article information

          Journal
          Food Chem
          Food chemistry
          0308-8146
          0308-8146
          Dec 15 2014
          : 165
          Affiliations
          [1 ] Centre for Pharmacognosy and Phytotherapy, UCL School of Pharmacy, University of London, 29-39 Brunswick Square, London WC1N 1AX, UK.
          [2 ] Plantextrakt GmbH & Co. KG, Dutendorfer Str. 5-7, D-91487 Vestenbergsgreuth, Germany.
          [3 ] Phytolab GmbH & Co. KG, Dutendorfer Str. 5-7, D-91487 Vestenbergsgreuth, Germany.
          [4 ] Centre for Pharmacognosy and Phytotherapy, UCL School of Pharmacy, University of London, 29-39 Brunswick Square, London WC1N 1AX, UK; Phytolab GmbH & Co. KG, Dutendorfer Str. 5-7, D-91487 Vestenbergsgreuth, Germany.
          [5 ] Centre for Pharmacognosy and Phytotherapy, UCL School of Pharmacy, University of London, 29-39 Brunswick Square, London WC1N 1AX, UK. Electronic address: m.heinrich@ucl.ac.uk.
          Article
          S0308-8146(14)00692-X
          10.1016/j.foodchem.2014.05.002
          25038696
          ceabcaa7-cdec-4e3c-bf7a-3be19664fb34
          Copyright © 2014 The Authors. Published by Elsevier Ltd.. All rights reserved.
          History

          Anthocyanins,Anti-diabetic,Anti-oxidant,Hibiscus acid,Hydroxycitric acid,Lipid metabolism (anti-cholesterol),Malvaceae,Nephro- and hepato-protective,Protocatechuic acid,Renal/diuretic effect,Roselle

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