• Record: found
  • Abstract: found
  • Article: not found

Factors associated with the prevalence and incidence of herpes simplex virus type 2 infection among men in Rakai, Uganda.

The Journal of Infectious Diseases

Adolescent, Adult, Alcohol Drinking, Circumcision, Male, Condoms, Confidence Intervals, HIV Seropositivity, epidemiology, transmission, HIV-1, HIV-2, Herpes Genitalis, Herpesvirus 2, Human, Humans, Incidence, Male, Middle Aged, Multivariate Analysis, Odds Ratio, Prevalence, Risk Factors, Sexual Behavior, Uganda, Young Adult

Read this article at

      There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.


      Little is known about risk factors for incident herpes simplex virus type 2 (HSV-2) infection among men in Africa. In a trial in Rakai, Uganda, 6396 men aged 15-49 years were evaluated for serological evidence of HSV-2, human immunodeficiency virus (HIV), and syphilis infections at enrollment and at 6, 12, and 24 months. The prevalence of HSV-2 infection was 33.76%, and the incidence was 4.90 cases per 100 person-years. HSV-2 incidence increased with alcohol use with sexual intercourse (adjusted incidence rate ratio [adjIRR], 1.92 [95% confidence interval {CI}, 1.46-2.53]), decreased with consistent condom use (adjIRR, 0.56 [95% CI, 0.36-0.89]) and male circumcision (adjIRR, 0.70 [95% CI, 0.55-0.91]), and was not significantly affected by enrollment HIV status. Education on modifiable behavioral changes may reduce the acquisition of HSV-2. ( identifiers: NCT00425984 and NCT00124878 .).

      Related collections

      Author and article information



      Comment on this article