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      Prediction of Creatinine Clearance from Serum Creatinine

      ,

      Nephron

      S. Karger AG

      Serum creatinine, Creatinine clearance, Creatinine excretion, Renal function, Age

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          Abstract

          A formula has been developed to predict creatinine clearance (C<sub>cr</sub>) from serum creatinine (S<sub>cr</sub>) in adult males: Ccr = (140 – age) (wt kg)/72 × S<sub>cr</sub>(mg/100ml) (15% less in females). Derivation included the relationship found between age and 24-hour creatinine excretion/kg in 249 patients aged 18–92. Values for C<sub>cr</sub> were predicted by this formula and four other methods and the results compared with the means of two 24-hour C<sub>cr’s</sub> measured in 236 patients. The above formula gave a correlation coefficient between predicted and mean measured Ccr·s of 0.83; on average, the difference between predicted and mean measured values was no greater than that between paired clearances. Factors for age and body weight must be included for reasonable prediction.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1976
          1976
          28 November 2008
          : 16
          : 1
          : 31-41
          Affiliations
          Departments of Medicine, Queen Mary Veterans’ Hospital, Montreal, Quebec, and Memorial University, St. John’s, Newfoundland
          Article
          180580 Nephron 1976;16:31–41
          10.1159/000180580
          1244564
          © 1976 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 11
          Categories
          Paper

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