2014 Clinical Practice Guidelines for Overweight and Obesity in Korea

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Abstract

The dramatic increase in the prevalence of obesity and its accompanying comorbidities are major health concerns in Korea. Obesity is defined as a body mass index ≥25 kg/m ² in Korea. Current estimates are that 32.8% of adults are obese: 36.1% of men and 29.7% of women. The prevalence of being overweight and obese in national surveys is increasing steadily. Early detection and the proper management of obesity are urgently needed. Weight loss of 5% to 10% is the standard goal. In obese patients, control of cardiovascular risk factors deserves the same emphasis as weight-loss therapy. Since obesity is multifactorial, proper care of obesity requires a coordinated multidisciplinary treatment team, as a single intervention is unlikely to modify the incidence or natural history of obesity.

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Epidemic obesity and type 2 diabetes in Asia.

Kun-Ho Yoon, Jin-Hee Lee, Ji-Won Kim … (2006)

The proportions of people with type 2 diabetes and obesity have increased throughout Asia, and the rate of increase shows no sign of slowing. People in Asia tend to develop diabetes with a lesser degree of obesity at younger ages, suffer longer with complications of diabetes, and die sooner than people in other regions. Childhood obesity has increased substantially and the prevalence of type 2 diabetes has now reached epidemic levels in Asia. The health consequences of this epidemic threaten to overwhelm health-care systems in the region. Urgent action is needed, and advocacy for lifestyle changes is the first step. Countries should review and implement interventions, and take a comprehensive and integrated public-health approach. At the level of primary prevention, such programmes can be linked to other non-communicable disease prevention programmes that target lifestyle-related issues. The cost of inaction is clear and unacceptable.

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Body-mass index and mortality in Korean men and women.

Sun Jee, Jae Sull, Jungyong Park … (2006)

Obesity is associated with diverse health risks, but the role of body weight as a risk factor for death remains controversial. We examined the association between body weight and the risk of death in a 12-year prospective cohort study of 1,213,829 Koreans between the ages of 30 and 95 years. We examined 82,372 deaths from any cause and 48,731 deaths from specific diseases (including 29,123 from cancer, 16,426 from atherosclerotic cardiovascular disease, and 3362 from respiratory disease) in relation to the body-mass index (BMI) (the weight in kilograms divided by the square of the height in meters). In both sexes, the average baseline BMI was 23.2, and the rate of death from any cause had a J-shaped association with the BMI, regardless of cigarette-smoking history. The risk of death from any cause was lowest among patients with a BMI of 23.0 to 24.9. In all groups, the risk of death from respiratory causes was higher among subjects with a lower BMI, and the risk of death from atherosclerotic cardiovascular disease or cancer was higher among subjects with a higher BMI. The relative risk of death associated with BMI declined with increasing age. Underweight, overweight, and obese men and women had higher rates of death than men and women of normal weight. The association of BMI with death varied according to the cause of death and was modified by age, sex, and smoking history. Copyright 2006 Massachusetts Medical Society.

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A one-year randomized trial of lorcaserin for weight loss in obese and overweight adults: the BLOSSOM trial.

Meredith C. Fidler, Matilde Sanchez, Brian Raether … (2011)

Lorcaserin is a novel selective agonist of the serotonin 2C receptor. Our objective was to evaluate the effects of lorcaserin on body weight, cardiovascular risk factors, and safety in obese and overweight patients. This randomized, placebo-controlled, double-blind, parallel arm trial took place at 97 U.S. research centers. Patients included 4008 patients, aged 18-65 yr, with a body mass index between 30 and 45 kg/m(2) or between 27 and 29.9 kg/m(2) with an obesity-related comorbid condition. Patients were randomly assigned in a 2:1:2 ratio to receive lorcaserin 10 mg twice daily (BID), lorcaserin 10 mg once daily (QD), or placebo. All patients received diet and exercise counseling. The ordered primary endpoints were proportion of patients achieving at least 5% reduction in body weight, mean change in body weight, and proportion of patients achieving at least 10% reduction in body weight at 1 yr. Serial echocardiograms monitored heart valve function. Significantly more patients treated with lorcaserin 10 mg BID and QD lost at least 5% of baseline body weight (47.2 and 40.2%, respectively) as compared with placebo (25.0%, P < 0.001 vs. lorcaserin BID). Least squares mean (95% confidence interval) weight loss with lorcaserin BID and QD was 5.8% (5.5-6.2%) and 4.7% (4.3-5.2%), respectively, compared with 2.8% (2.5-3.2%) with placebo (P < 0.001 vs. lorcaserin BID; least squares mean difference, 3.0%). Weight loss of at least 10% was achieved by 22.6 and 17.4% of patients receiving lorcaserin 10 mg BID and QD, respectively, and 9.7% of patients in the placebo group (P < 0.001 vs. lorcaserin BID). Headache, nausea, and dizziness were the most common lorcaserin-related adverse events. U.S. Food and Drug Administration-defined echocardiographic valvulopathy occurred in 2.0% of patients on placebo and 2.0% on lorcaserin 10 mg BID. Lorcaserin administered in conjunction with a lifestyle modification program was associated with dose-dependent weight loss that was significantly greater than with placebo.

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Author and article information

Journal

Journal ID (nlm-ta): Endocrinol Metab (Seoul)

Journal ID (iso-abbrev): Endocrinol Metab (Seoul)

Journal ID (publisher-id): ENM

Title: Endocrinology and Metabolism

Publisher: Korean Endocrine Society

ISSN (Print): 2093-596X

ISSN (Electronic): 2093-5978

Publication date (Print): December 2014

Publication date (Electronic): 29 December 2014

Volume: 29

Issue: 4

Pages: 405-409

Affiliations

[1 ]Department of Internal Medicine, The Catholic University of Korea College of Medicine, Seoul, Korea.

[2 ]Department of Internal Medicine, Sungkyunkwan University School of Medicine, Seoul, Korea.

[3 ]Department of Family Medicine, Inje University Seoul Paik Hospital, Inje University College of Medicine, Seoul, Korea.

[4 ]Department of Family Medicine, Konyang University Hospital, Konyang University College of Medicine, Daejeon, Korea.

[5 ]Department of Family Medicine, Ajou University School of Medicine, Suwon, Korea.

[6 ]Department of Family Medicine, Korea University College of Medicine, Seoul, Korea.

[7 ]Department of Dietetics, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.

[8 ]Department of Physical Education, Yonsei University, Seoul, Korea.

[9 ]Department of Pediatrics, National Medical Center, Seoul, Korea.

[10 ]Department of Family Medicine, Gachon University Dongincheon Gil Hospital, Gachon University of Medicine and Science, Incheon, Korea.

[11 ]Department of Internal Medicine, Gachon University Gil Hospital, Gachon University of Medicine and Science, Incheon, Korea.

[12 ]Department of Family Medicine, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, Yangsan, Korea.

[13 ]Department of Family Medicine, Sanggye Paik Hospital, Inje University, Seoul, Korea.

[14 ]Department of Internal Medicine, Eulji University Hospital, Eulji University School of Medicine, Daejeon, Korea.

[15 ]Department of Internal Medicine, Hanyang University Guri Hospital, Hanyang University College of Medicine, Guri, Korea.

[16 ]Department of Pediatrics, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, Korea.

[17 ]Department of Internal Medicine, Kyung Hee University School of Medicine, Seoul, Korea.

[18 ]Department of Surgery, Soonchunhyang University College of Medicine, Seoul, Korea.

[19 ]Department of Family Medicine, Chungnam National University School of Medicine, Daejeon, Korea.

Author notes

Corresponding authors: Sung Soo Kim. Department of Family Medicine, Chungnam National University Hospital, Chungnam National University School of Medicine, 282 Munhwa-ro, Jung-gu, Daejeon 301-721, Korea. Tel: +82-42-280-8111, Fax: +82-42-280-8111, sungsoo@ 123456cnu.ac.kr

Corresponding authors: Jeong-Taek Woo. Department of Internal Medicine, Kyung Hee University Hospital, Kyung Hee University School of Medicine, 23 Kyungheedae-ro, Dongdaemun-gu, Seoul 130-872, Korea. Tel: +82-2-958-8199, Fax: +82-2-968-1848, jtwoomd@ 123456khmc.or.kr

Article

DOI: 10.3803/EnM.2014.29.4.405

PMC ID: 4285036

PubMed ID: 25559568

SO-VID: ceea6b1c-4b0a-424d-b342-c9bfb3fdc73a

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This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

2014 Clinical Practice Guidelines for Overweight and Obesity in Korea

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Most cited references 18

Epidemic obesity and type 2 diabetes in Asia.

Body-mass index and mortality in Korean men and women.

A one-year randomized trial of lorcaserin for weight loss in obese and overweight adults: the BLOSSOM trial.

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