+1 Recommend
1 collections
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Ototoxicidade por organofosforados: descrição dos aspectos ultraestruturais do sistema vestibulococlear de cobaias Translated title: Organophosphate-related ototoxicity: Description of the vestibulocochlear system ultrastructural aspects of guinea pigs


      Read this article at

          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.


          Os agrotóxicos organofosforados são amplamente utilizados na agricultura, e atualmente fazem parte do grupo de agentes químicos que podem levar à perda auditiva, no qual já estavam incluídos os solventes, os metais e os asfixiantes. OBJETIVO: Analisar a ação ototóxica aguda de um agrotóxico do grupo dos organofosforados na citoarquitetura do sistema vestibulococlear. Trata-se de um estudo experimental prospectivo. MATERIAL E MÉTODO: Foram utilizadas cobaias albinas machos, divididas em três grupos, nos quais se administrou água destilada (grupo 1 - controle), agrotóxico - 0,3mg/Kg/dia (grupo 2), agrotóxico - 3 mg/Kg/dia (grupo 3), durante sete dias consecutivos. O agrotóxico utilizado foi Tamaron BR (metamidofós). A avaliação anatômica da cóclea, sáculo e utrículo foi realizada através da microscopia eletrônica de varredura, após o período de aplicação do agrotóxico. RESULTADOS: As cobaias submetidas ao organofosforado apresentaram alterações morfológicas cocleares, com lesões nas três espiras analisadas, bem como alterações ciliares de sáculo e utrículo, intensificadas de acordo com a dosagem recebida do agente. CONCLUSÃO: As alterações morfológicas observadas nas células ciliadas nos grupos expostos a doses diárias de organofosforado promovem evidências de um efeito agudo degradante dos agrotóxicos no sistema vestibulococlear.

          Translated abstract

          Organophosphate toxic agents are used in agriculture and are currently part of the group of toxic agents which can lead to hearing loss, in which we have solvents, metals and asphyxiation agents. AIM: to analyze the acute ototoxic action of a group of organophosphate agents in the vestibulo-cochlear system. This is a prospective experimental study. MATERIALS AND METHODS: we used male albino guinea pigs, broken down into three groups, to which we provided distilled water (group 1 - control), agrotoxic agent - 0.3mg/Kg/day (group 2), agrotoxic - 3 mg/Kg/day (group 3), during 7 seven consecutive days. The most used agrotoxic agent was Tamaron BR (metamidophos). The anatomical evaluation of the cochlea, saccule and utricle was carried out by means of electronic scanning microscopy after the use of the agrotoxic agent. RESULTS: the guinea pigs submitted to the organophosphate presented cochlear morphological alterations with lesions on the three turns analyzed, as well as cilia alterations in the saccule and utricle, intensified according to the agent dosage. CONCLUSION: the morphological alterations seen in the hair cells exposed to daily doses of organophosphate promote evidences of an acute deleterious effect of agrotoxic agents on the vestibulo-cochlear system.

          Related collections

          Most cited references 35

          • Record: found
          • Abstract: found
          • Article: not found

          Chemical exposure as a risk factor for hearing loss.

           T Morata (2003)
          In 2002, the National Institute for Occupational Safety and Health and the National Hearing Conservation Association cosponsored the "Best Practices Workshop: Combined Effects of Chemicals and Noise on Hearing." This article summarizes the main results of the Workshop. Its goals were to review the knowledge of chemical ototoxicity and to stimulate participant discussion on how to address this risk. Speakers provided an overview of the effects of chemicals on the auditory system (http://www.cdc.gov/niosh/noise/noiseandchem/noiseandchem.html). Research priorities were discussed in concurrent working group sessions. The Workshop concluded with a panel of the groups' facilitators reporting on these sessions. The following key issues were identified: rationale and proposal of a list of priority chemicals; valid procedures for exposure (animal studies), exposure assessment, and audiological testing; need for mechanistic research and a Response Level; recommendations for preventive actions; and information dissemination.
            • Record: found
            • Abstract: not found
            • Article: not found

            Efeito de produtos químicos e ruído na gênese de perda auditiva ocupacional

              • Record: found
              • Abstract: not found
              • Article: not found

              Manual sobre Cuidados e Usos de Animais de Laboratório


                Author and article information

                Role: ND
                Role: ND
                Role: ND
                Role: ND
                Brazilian Journal of Otorhinolaryngology
                Braz. j. otorhinolaryngol.
                Associação Brasileira de Otorrinolaringologia e Cirurgia Cervicofacial (São Paulo )
                April 2010
                : 76
                : 2
                : 238-244
                [1 ] Universidade Federal de Santa Maria Brazil
                [2 ] Universidade Federal de Santa Maria Brazil
                [3 ] Universidade de São Paulo Brazil
                Product Information: website


                Comment on this article