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      Sevoflurane in combination with propofol, not thiopental, induces a more robust neuroapoptosis than sevoflurane alone in the neonatal mouse brain.

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          Abstract

          Sevoflurane is the most widely used volatile anesthetic of general anesthesia. In children and neonates, it is commonly used alone or in combination with thiopental or propofol. A few recent studies reported that sevoflurane induced neuronal death in the developing rodent brain. We measured the neurotoxicity of these anesthetics at clinical doses, alone and in combination, in the developing mouse brain.

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          Author and article information

          Journal
          J Anesth
          Journal of anesthesia
          Springer Nature
          1438-8359
          0913-8668
          Dec 2014
          : 28
          : 6
          Affiliations
          [1 ] Department of Neural Regeneration and Cell Communication, Mie University Graduate School of Medicine, 2-174 Edobashi, Tsu, Mie, 514-8507, Japan, tsuyoshitagawa@gmail.com.
          Article
          10.1007/s00540-014-1822-x
          24705982
          cf0a2cce-632e-45a3-9f9e-8a66330cabc8
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