TGF-β1-induced phospholamban expression alters esophageal smooth muscle cell contraction in patients with eosinophilic esophagitis.

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Abstract

Eosinophilic esophagitis (EoE) is a chronic antigen-mediated disease characterized by esophageal eosinophilia, remodeling, and fibrosis. TGF-β1 is a central regulator of EoE remodeling and increases esophageal smooth muscle (ESM) cell contraction.

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Journal

Journal ID (iso-abbrev): J. Allergy Clin. Immunol.

Title: The Journal of allergy and clinical immunology

Publisher: Elsevier BV

ISSN (Electronic): 1097-6825

ISSN (Print): 0091-6749

Publication date (Electronic): Nov 2014

Volume: 134

Issue: 5

Affiliations

[1 ] Division of Allergy and Immunology, University of California, San Diego, Calif; Department of Pediatrics, University of California, San Diego, Calif.

[2 ] Division of Allergy and Immunology, University of California, San Diego, Calif; Department of Medicine, University of California, San Diego, Calif.

[3 ] Department of Pediatrics, University of California, San Diego, Calif; Division of Pathology, University of California, San Diego, Calif.

[4 ] Department of Pediatrics, University of California, San Diego, Calif; Division of Gastroenterology, University of California, San Diego, Calif.

[5 ] Division of Allergy and Immunology, University of California, San Diego, Calif; Department of Pediatrics, University of California, San Diego, Calif; Department of Medicine, University of California, San Diego, Calif. Electronic address: saceves@ucsd.edu.

Article

Publisher Item ID: S0091-6749(14)00523-5 Mid ID: NIHMS585767

DOI: 10.1016/j.jaci.2014.04.004

PMC ID: 4231011

PubMed ID: 24835503

SO-VID: cf1e9ecd-c691-4df5-bc9e-24e70ca9f7cf

History

Keywords: Remodeling,TGF-β,eosinophils,esophagus,phospholamban,smooth muscle

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Keywords: Remodeling, TGF-β, eosinophils, esophagus, phospholamban, smooth muscle

TGF-β1-induced phospholamban expression alters esophageal smooth muscle cell contraction in patients with eosinophilic esophagitis.

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