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      Optical coherence tomography angiography in glaucoma: a mini-review

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          Abstract

          The advent of optical coherence tomography angiography (OCT-A) provides a new opportunity to visualize the retinal vasculature in a non-invasive and dye-free manner which may help identify vascular abnormalities in glaucoma. While a reduction in retinal and optic nerve head vessel densities and blood flow indexes measured by OCT-A has been demonstrated in patients with glaucoma in many studies, it is unclear whether OCT-A provides additional information for the detection and monitoring of glaucoma compared with OCT measurements such as retinal nerve fiber layer thickness, neuroretinal rim width, and ganglion cell inner plexiform layer thickness. Longitudinal studies are needed to elucidate whether vascular abnormalities detected by OCT-A are a cause or a consequence of optic nerve damage in glaucoma.

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          Optical coherence tomography angiography of optic disc perfusion in glaucoma.

          To compare optic disc perfusion between normal subjects and subjects with glaucoma using optical coherence tomography (OCT) angiography and to detect optic disc perfusion changes in glaucoma.
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            Optical Coherence Tomography Angiography of the Peripapillary Retina in Glaucoma.

            Vascular factors may have important roles in the pathophysiology of glaucoma. A practical method for the clinical evaluation of ocular perfusion is needed to improve glaucoma management.
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              Optical Coherence Tomography Angiography

              Optical coherence tomography angiography (OCTA) is a noninvasive approach that can visualize blood vessels down to the capillary level. With the advent of high-speed OCT and efficient algorithms, practical OCTA of ocular circulation is now available to ophthalmologists. Clinical investigations that used OCTA have increased exponentially in the past few years. This review will cover the history of OCTA and survey its most important clinical applications. The salient problems in the interpretation and analysis of OCTA are described, and recent advances are highlighted.
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                Author and article information

                Journal
                F1000Res
                F1000Res
                F1000Research
                F1000Research
                F1000Research (London, UK )
                2046-1402
                14 September 2017
                2017
                : 6
                : 1686
                Affiliations
                [1 ]Department of Ophthalmology, Tuen Mun Eye Center and Tuen Mun Hospital, Hong Kong, China
                [2 ]Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, China
                Author notes

                Competing interests: KW declares that he has no competing interests. CL has received speaker honoraria from Carl Zeiss Meditec and Heidelberg Engineering and research support from Carl Zeiss Meditec.

                Article
                10.12688/f1000research.11691.1
                5600001
                cf2f9b68-9902-466c-be3e-fd880f168744
                Copyright: © 2017 Wan KH and Leung CKS

                This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                : 15 September 2017
                Funding
                The author(s) declared that no grants were involved in supporting this work.
                Categories
                Review
                Articles
                Glaucoma
                Retinal, Vitreous & Macular Disorders

                optical coherence tomography angiography,glaucoma,retina,optic nerve head,vascular abnormalities,optical imaging

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