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      Dietary Exposure to Aluminium and Health Risk Assessment in the Residents of Shenzhen, China

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          Abstract

          Although there are great changes of dietary in the past few decades in China, few are known about the aluminium exposure in Chinese diet. The aim of this study is to systematically evaluate the dietary aluminium intake level in residents of Shenzhen, China. A total of 853 persons from 244 household were investigated their diet by three days food records. Finally, 149 kinds of foods in 17 food groups were selected to be the most consumed foods. From them, 1399 food samples were collected from market to test aluminium concentration. High aluminium levels were found in jellyfish (median, 527.5 mg/kg), fried twisted cruller (median, 466.0 mg/kg), shell (median, 107.1 mg/kg). The Shenzhen residents' average dietary aluminium exposure was estimated at 1.263 mg/kg bw/week which is lower than the PTWI (provisional tolerable weekly intake). But 0–2 and 3–13 age groups have the highest aluminium intake exceeding the PTWI (3.356 mg/kg bw/week and 3.248 mg/kg bw/week) than other age groups. And the main dietary aluminium exposure sources are fried twisted cruller, leaf vegetables and bean products. Our study suggested that even three decades rapid economy development, children in Shenzhen still have high dietary aluminium exposure risk. How to control high dietary aluminium exposure still is a great public health challenge in Shenzhen, China.

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          Most cited references22

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          Human health risk assessment for aluminium, aluminium oxide, and aluminium hydroxide.

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            Dietary exposure to trace elements and health risk assessment in the 2nd French Total Diet Study.

            Dietary exposure of the French population to trace elements has been assessed in the second national Total Diet Study (TDS). Food samples (n = 1319) were collected between 2007 and 2009 to be representative of the whole diet of the population, prepared as consumed, and analyzed. Occurrence data were combined with national individual consumption data to estimate dietary exposure for adults and children mean and high consumers. Compared to the 1st French TDS performed in 2000-2004, exposure is higher for cadmium, aluminium, antimony, nickel, cobalt and lower for lead, mercury and arsenic. For aluminium, methylmercury, cadmium, lead and inorganic arsenic risk cannot be ruled out for certain consumer groups. It still appears necessary to continue undertaking efforts to reduce exposure to these elements. Due to the lack of robust toxicological data and/or speciation analysis in food on chromium, tin, silver and vanadium to perform a risk assessment, data on occurrence and dietary exposure are provided as Supplementary material. In order to minimize nutritional and chemical risks, the French Agency for Food, Environmental and Occupational Health & Safety (ANSES) reiterates its recommendation for a diversified diet (food items and origins). Copyright © 2012 Elsevier Ltd. All rights reserved.
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              Aluminium in Alzheimer's disease: are we still at a crossroad?

              Aluminium, an environmentally abundant non-redox trivalent cation has long been implicated in the pathogenesis of Alzheimer's disease (AD). However, the definite mechanism of aluminium toxicity in AD is not known. Evidence suggests that trace metal homeostasis plays a crucial role in the normal functioning of the brain, and any disturbance in it can exacerbate events associated with AD. The present paper reviews the scientific literature linking aluminium with AD. The focus is on aluminium levels in brain, region-specific and subcellular distribution, its relation to neurofibrillary tangles, amyloid beta, and other metals. A detailed mechanism of the role of aluminium in oxidative stress and cell death is highlighted. The importance of complex speciation chemistry of aluminium in relation to biology has been emphasized. The debatable role of aluminium in AD and the cross-talk between aluminium and genetic susceptibility are also discussed. Finally, it is concluded based on extensive literature that the neurotoxic effects of aluminium are beyond any doubt, and aluminium as a factor in AD cannot be discarded. However, whether aluminium is a sole factor in AD and whether it is a factor in all AD cases still needs to be understood.
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                Author and article information

                Contributors
                Role: Editor
                Journal
                PLoS One
                PLoS ONE
                plos
                plosone
                PLoS ONE
                Public Library of Science (San Francisco, USA )
                1932-6203
                2014
                3 March 2014
                : 9
                : 3
                : e89715
                Affiliations
                [1 ]Department of Health Surveillance and Management, Futian District Center for Disease Control and Prevention of Shenzhen, Shenzhen, Guangdong, China
                [2 ]Department of Laboratory, Futian District Center for Disease Control and Prevention of Shenzhen, Shenzhen, Guangdong, China
                [3 ]Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, Hubei, China
                The Ohio State University, United States of America
                Author notes

                Competing Interests: The authors have declared that no competing interests exist.

                Conceived and designed the experiments: M. Yang SW. Performed the experiments: M. Yang LJ HH SZ FQ. Analyzed the data: M. Yang XL M. Yu. Contributed reagents/materials/analysis tools: LJ HH SZ FQ. Wrote the paper: M. Yang M. Yu SW.

                Article
                PONE-D-13-39167
                10.1371/journal.pone.0089715
                3940618
                24594670
                cf31fec8-a93b-4daf-9171-5652e44fb982
                Copyright @ 2014

                This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

                History
                : 23 September 2013
                : 21 January 2014
                Page count
                Pages: 8
                Funding
                This work was supported by Medical Scientific Research Foundation of Guangdong Province, China (A2012591). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
                Categories
                Research Article
                Agriculture
                Crops
                Vegetables
                Medicine
                Epidemiology
                Epidemiological Methods
                Epidemiology of Aging
                Lifecourse Epidemiology
                Social Epidemiology
                Survey Methods
                Non-Clinical Medicine
                Health Care Policy
                Health Risk Analysis
                Nutrition
                Eating Disorders
                Public Health
                Child Health

                Uncategorized
                Uncategorized

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