Arsenic, antimony, and Leishmania: has arsenic contamination of drinking water in India led to treatment- resistant kala-azar?

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Abstract

In Bihar state, India, the cure rate of antimonial compounds (eg, sodium stibogluconate) in the treatment of visceral leishmaniasis (VL) has fallen from more than 85% to less than 50%. This reduction has been attributed to long-term, widespread misuse of antimonial drugs within the Indian private health-care system. We aimed to test the hypothesis that exposure to arsenic in drinking water in this region has resulted in antimony-resistant Leishmania parasites.

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Journal

Journal ID (iso-abbrev): Lancet

Title: Lancet (London, England)

Publisher: Elsevier BV

ISSN (Electronic): 1474-547X

ISSN (Print): 0140-6736

Publication date (Electronic): Feb 26 2015

Volume: 385 Suppl 1

Affiliations

[1 ] Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee, UK. Electronic address: meghanperry79@yahoo.co.uk.

[2 ] Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee, UK.

[3 ] Department of Biochemistry, Central University of Rajasthan, Rajasthan, India.

[4 ] Department of Public Health, Institute of Tropical Medicine, Antwerp, Belgium.

[5 ] College of Physical Sciences - Chemistry, Trace Element Speciation Laboratory, University of Aberdeen, Aberdeen, UK.

[6 ] School of Environmental Studies, Jadavpur University, Kolkata, India.

[7 ] Infectious Disease Research Laboratory, Department of Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India.

[8 ] Barcelona Centre for International Health Research, Hospital Clinic Universitat de Barcelona, Barcelona, Spain.

Article

Publisher Item ID: S0140-6736(15)60395-6

DOI: 10.1016/S0140-6736(15)60395-6

PubMed ID: 26312902

SO-VID: cf3404ef-51ee-4c3a-9601-dc11db3948d7

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