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      Long-Term Results in 35 HLA-Identical Sibling and 3 HLA-Identical Parent-Child Renal Allograft Recipients

      ,

      Nephron

      S. Karger AG

      HLA-identical siblings and parents, Cytomegalovirus, Aseptic necrosis, Lipids, Histocompatibility

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          Abstract

          35 recipients of a renal allograft from an HLA-identical sibling followed for 3 months to nearly 15 years have had 1- and 5-year allograft survivals of 93 and 76%, respectively, levels comparable to the 90 and 80% reported at 1 and 5 years for identical twins. Although high MLC stimulation was related to graft failure, intermediate degrees of stimulation were not. The most common cause of graft failure was chronic rejection (n = 4) and of death, myocardial infarction (n = 3). However, overall complications such as aseptic necrosis were distinctly lower than in mismatched recipients. 3 children received an allograft from an HLA-identical parent, possible because of a shared parental haplotype, and all have excellent function from 2 to nearly 9 years after transplantation.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          978-3-8055-2981-5
          978-3-318-02025-0
          1660-8151
          2235-3186
          1978
          1978
          02 December 2008
          : 22
          : 1-3
          : 232-238
          Affiliations
          Cleveland Clinic Foundation, Cleveland, Ohio
          Article
          181454 Nephron 1978;22:232–238
          10.1159/000181454
          154617
          © 1978 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 7
          Categories
          Original Paper

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