+1 Recommend
1 collections
      Call for Papers in Kidney and Blood Pressure ResearchKidney Function and Omics Science

      Submission Deadline: December 20, 2023

      Submit now

      • Record: found
      • Abstract: found
      • Article: found

      Studies on Mechanism of Hypophosphaturia after Relief of Unilateral Ureteral Obstruction


      Read this article at

          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.


          The effect of unilateral ureteral obstruction (UUO) of 48 h duration on phosphate excretion was studied in dogs. After the relief of UUO, the fraction of filtered phosphate excreted (FEP) was markedly reduced while that of sodium (FENa) was significantly increased as compared to the normal kidney. Extracellular fluid volume expansion (ECVE) in dogs with intact parathyroid glands and in those with thyroparathyroidectomy produced marked phosphaturia from both kidneys but significantly less from the obstructed one. Infusion of parathyroid extract (PTE) to dogs with intact parathyroid glands caused similar effects to those seen with ECVE; PTE infusion also caused a significant but equal rise in urinary cyclic AMP. In other groups of animals, acute hypoperfusion of the left kidney was produced by constriction of the aorta between the origin of the renal arteries. The patterns of FEP noted from both kidneys in these dogs during ECVE and infusion of PTE were qualitatively similar to those seen in dogs with UUO. The results indicate that (1) there is a dissociation between the renal handling of phosphate and sodium after relief of UUO, and (2) the reduced basal FEP and the blunted phosphaturic response to ECVE and infusion of PTE observed in the obstructed kidney may be due to the renal hypoperfusion secondary to UUO. The data are consistent with the notion that unilateral ureteral obstruction is associated with enhanced phosphate reabsorption in the proximal tubule and decreased sodium reabsorption at a site distal to the proximal tubule.

          Related collections

          Author and article information

          S. Karger AG
          02 December 2008
          : 19
          : 6
          : 333-341
          University of Southern California, Division of Nephrology and Department of Medicine, Los Angeles, Calif.
          180911 Nephron 1977;19:333–341
          © 1977 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          : 14 May 1976
          : 15 October 1976
          Page count
          Pages: 9
          Original Paper

          Cardiovascular Medicine,Nephrology
          Extracellular volume expansion,Ureteral obstruction,Cyclic AMP,Hypophosphatemia,Parathyroid hormone,Renal hypoperfusion


          Comment on this article