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      Renal Reabsorption of Phosphate in Children with Sickle Cell Anemia

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          It has previously been reported that in adult patients with sickle-cell anemia the serum phosphate value and the maximum tubular reabsorption of phosphate per liter of glomerular filtrate (TmP/GFR) were significantly higher than in normal controls. This does not appear to have been studied in children with sickle cell anemia (young sicklers) and this prompted us to assess renal phosphate reabsorption in this group of patients. We looked at serum phosphate level and calculated renal phosphate reabsorption (TP/GFR) in children taking random urine and blood samples at the same time and using the formula TP/GFR = Sp – Up × SCr: UCr, in 30 young sicklers all of whom had normal renal function (mean age 7.3 years) and 40 normal matching controls (mean age 6.5 years). The mean serum phosphate value in young sicklers was significantly lower than in controls (4.3 against 5.3 mg/dl) while the mean value of TP/GFR was 4.09 ± 0.74 mg/dl in young sicklers compared to 4.65 ± 0.75 mg/dl in the control group (p = 0.0026). Therefore, the TP/GFR in young sicklers was also significantly lower (p = 0.0026) than in the control group. This may be explained by the high serum level of parathyroid hormone reported previously in patients with sickle cell anemia which is expected to lower phosphate reabsorption (TmP/GFR and TP/GFR are identical in children). The lower serum phosphate value and TP/GFR in younger sicklers seems to be in contrast with the relatively high serum phosphate value and TP/GFR previously reported in adults with sickle cell anemia.

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          Author and article information

          Am J Nephrol
          American Journal of Nephrology
          S. Karger AG
          October 1999
          26 November 1999
          : 19
          : 5
          : 552-554
          Departments of aChild Health and bPhysiology, College of Medicine, King Saud University-Abha Branch, and cDepartment of Paediatrics, Asir Central Hospital, Abha, Kingdom of Saudi Arabia
          13518 Am J Nephrol 1999;19:552–554
          © 1999 S. Karger AG, Basel

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          Page count
          Tables: 1, References: 8, Pages: 3
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          Clinical Study

          Cardiovascular Medicine, Nephrology

          Phosphate, Children, Urine, Reabsorption, Sickle cell anemia, Serum


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