Teses sobre hepatites na Faculdade de Medicina da Universidade Federal do Rio de Janeiro, 1837-2000

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Abstract

Apresenta inventário das teses sobre hepatites da Faculdade de Medicina da Universidade Federal do Rio de Janeiro entre 1837 e 2000. A análise indica potencialidades e limites para discussão do quadro evolutivo do conhecimento científico no Brasil sobre esses agravos. As teses também são discutidas à luz de seus referenciais científicos e das mudanças tecnológicas e sociais que as influenciaram. Identificam-se e categorizam-se os marcos do ensino médico e do conhecimento sobre as hepatites, considerando que as teses revelam, no mínimo, o estado da arte de seu objeto. O estudo permitiu explorar as bases em que os saberes científicos sobre as hepatites foram construídos e indicar possibilidades de pesquisas na reconstrução do conhecimento científico de outros agravos.

Translated abstract

An inventory of the theses on hepatitis of the Faculdade de Medicina of the Universidade Federal do Rio de Janeiro between 1837 and 2000 is presented. The analysis indicates the potential and limits for discussion of the evolutionary framework of scientific knowledge on these health problems in Brazil. The theories are also discussed in light of their scientific reference points and the technological and social changes that influenced them. The landmarks in medical education and knowledge about hepatitis are identified and categorized, considering that the theses reveal at the very least the state of the art on the subject. The study makes it possible to explore the foundations upon which the scientific knowledge on hepatitis were built and indicate possibilities for research in the reconstruction of scientific knowledge of other health problems.

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Most cited references 55

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Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome.

Serena G L Choo, Celine Choo, Beverly Bradley … (1989)

A random-primed complementary DNA library was constructed from plasma containing the uncharacterized non-A, non-B hepatitis (NANBH) agent and screened with serum from a patient diagnosed with NANBH. A complementary DNA clone was isolated that was shown to encode an antigen associated specifically with NANBH infections. This clone is not derived from host DNA but from an RNA molecule present in NANBH infections that consists of at least 10,000 nucleotides and that is positive-stranded with respect to the encoded NANBH antigen. These data indicate that this clone is derived from the genome of the NANBH agent and are consistent with the agent being similar to the togaviridae or flaviviridae. This molecular approach should be of great value in the isolation and characterization of other unidentified infectious agents.