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      A tension-based theory of morphogenesis and compact wiring in the central nervous system.

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      Nature
      Springer Science and Business Media LLC

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          Abstract

          Many structural features of the mammalian central nervous system can be explained by a morphogenetic mechanism that involves mechanical tension along axons, dendrites and glial processes. In the cerebral cortex, for example, tension along axons in the white matter can explain how and why the cortex folds in a characteristic species-specific pattern. In the cerebellum, tension along parallel fibres can explain why the cortex is highly elongated but folded like an accordion. By keeping the aggregate length of axonal and dendritic wiring low, tension should contribute to the compactness of neural circuitry throughout the adult brain.

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          Author and article information

          Journal
          Nature
          Nature
          Springer Science and Business Media LLC
          0028-0836
          0028-0836
          Jan 23 1997
          : 385
          : 6614
          Affiliations
          [1 ] Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110, USA. vanessen@vl.wustl.edu
          Article
          10.1038/385313a0
          9002514
          cf4df716-7823-42be-8489-4cdbb5cf9068
          History

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