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      Long-term stability of effects of subthalamic stimulation in Parkinson's disease: Indian Experience.

      Movement Disorders

      Treatment Outcome, Adult, Time Factors, physiology, Subthalamic Nucleus, Single-Blind Method, Retrospective Studies, Quality of Life, therapy, complications, Parkinson Disease, Neuropsychological Tests, Middle Aged, Male, Longitudinal Studies, therapeutic use, Levodopa, epidemiology, India, Humans, Female, Executive Function, etiology, Dyskinesias, methods, Deep Brain Stimulation, Cognition Disorders, Attention, Antiparkinson Agents

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          Reports of long-term effects of subthalamic (STN) stimulation for Parkinson's disease (PD) are few, mostly open-label evaluations and from Western centers. We used single-blind and open-label motor, cognitive and quality of life (QOL) evaluations to study the effects of bilateral STN stimulation in 45 patients over 5 years. Our patients showed a stable and substantial reduction in the cardinal signs of PD, motor fluctuations, and dyskinesias but less so for axial signs. The reduction in medications and the intensity of electrical stimulation needed also remained stable during follow up. Although the total QOL and its parkinsonism and social components showed sustained benefits till 5 years, the gains in emotional and systemic subsets were short lasting. Global scores for mood and cognition did not show significant worsening. Benefits of STN stimulation on the cardinal signs, motor complications, and QOL of advanced PD were substantial and sustained till 5 years. The initial benefits in axial motor signs and emotional and psychological aspects of QOL did not show similar stability. In general, the procedure had insignificant impact on cognition and mood. This is the first report of STN stimulation in Asian patients with PD.

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