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      Phenolic compounds from the roots of Jordanian viper's grass, Scorzonera judaica.

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          Abstract

          Nine new phenolic compounds, 3S-hydrangenol 40-O-R-L-rhamnopyranoysl-(1-->3)-β-D-glucopyranoside (1), thunberginol F 7-O-β-D-glucopyranoside (2), 2-hydroxy-6-[2-(4-hydroxyphenyl)-2-oxo-ethyl]benzoic acid (3), 2-hydroxy-6-[2-(3,4-dihydroxyphenyl)-2-oxo-ethyl]benzoic acid (4), 2-hydroxy-6-[2-(3,4-dihydroxyphenyl-5-methoxy)-2-oxoethyl]benzoic acid (5), hydrangeic acid 40-O-β-D-glucopyranoside (6), E-3-(3,4-dihydroxybenzylidene)-5-(3,4-dihydroxyphenyl)dihydrofuran-2-one (7), Z-3-(3,4-dihydroxybenzylidene)-5-(3,4-dihydroxyphenyl)-2(3H)-furanone (8), and 4-[β-D-glucopyranosyl)hydroxy]-pinoresinol (9), and nine known compounds were isolated from the roots of Scorzonera judaica. Structures of 1-9 were elucidated by mass spectrometry, extensive 1D and 2D NMR spectroscopy, and CD spectroscopy.All compounds were evaluated for cytotoxic activity.

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          Author and article information

          Journal
          J. Nat. Prod.
          Journal of natural products
          1520-6025
          0163-3864
          Jun 24 2011
          : 74
          : 6
          Affiliations
          [1 ] Faculty of Pharmacy, Al-Zaytoonah Private University of Jordan , P.O. Box 130, 11733 Amman, Jordan.
          Article
          10.1021/np200143s
          21650157
          cf5181a0-3f0a-4b91-89de-f2dc12fdf553
          History

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