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      3D Printing of Lotus Root‐Like Biomimetic Materials for Cell Delivery and Tissue Regeneration

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          Abstract

          Biomimetic materials have drawn more and more attention in recent years. Regeneration of large bone defects is still a major clinical challenge. In addition, vascularization plays an important role in the process of large bone regeneration and microchannel structure can induce endothelial cells to form rudimentary vasculature. In recent years, 3D printing scaffolds are major materials for large bone defect repair. However, these traditional 3D scaffolds have low porosity and nonchannel structure, which impede angiogenesis and osteogenesis. In this study, inspired by the microstructure of natural plant lotus root, biomimetic materials with lotus root‐like structures are successfully prepared via a modified 3D printing strategy. Compared with traditional 3D materials, these biomimetic materials can significantly improve in vitro cell attachment and proliferation as well as promote in vivo osteogenesis, indicating potential application for cell delivery and bone regeneration.

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          Most cited references39

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          Tough, bio-inspired hybrid materials.

          The notion of mimicking natural structures in the synthesis of new structural materials has generated enormous interest but has yielded few practical advances. Natural composites achieve strength and toughness through complex hierarchical designs that are extremely difficult to replicate synthetically. We emulate nature's toughening mechanisms by combining two ordinary compounds, aluminum oxide and polymethyl methacrylate, into ice-templated structures whose toughness can be more than 300 times (in energy terms) that of their constituents. The final product is a bulk hybrid ceramic-based material whose high yield strength and fracture toughness [ approximately 200 megapascals (MPa) and approximately 30 MPa.m(1/2)] represent specific properties comparable to those of aluminum alloys. These model materials can be used to identify the key microstructural features that should guide the synthesis of bio-inspired ceramic-based composites with unique strength and toughness.
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            Bioinspired Surfaces with Superwettability: New Insight on Theory, Design, and Applications.

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              Bioinspired design and assembly of platelet reinforced polymer films.

              Although strong and stiff human-made composites have long been developed, the microstructure of today's most advanced composites has yet to achieve the order and sophisticated hierarchy of hybrid materials built up by living organisms in nature. Clay-based nanocomposites with layered structure can reach notable stiffness and strength, but these properties are usually not accompanied by the ductility and flaw tolerance found in the structures generated by natural hybrid materials. By using principles found in natural composites, we showed that layered hybrid films combining high tensile strength and ductile behavior can be obtained through the bottom-up colloidal assembly of strong submicrometer-thick ceramic platelets within a ductile polymer matrix.
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                Author and article information

                Contributors
                xinquanj@aliyun.com
                chengtiewu@mail.sic.ac.cn
                Journal
                Adv Sci (Weinh)
                Adv Sci (Weinh)
                10.1002/(ISSN)2198-3844
                ADVS
                Advanced Science
                John Wiley and Sons Inc. (Hoboken )
                2198-3844
                26 October 2017
                December 2017
                : 4
                : 12 ( doiID: 10.1002/advs.v4.12 )
                : 1700401
                Affiliations
                [ 1 ] State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of Ceramics Chinese Academy of Sciences 1295 Dingxi Road Shanghai 200050 P. R. China
                [ 2 ] University of Chinese Academy of Sciences 19 Yuquan Road Beijing 100049 P. R. China
                [ 3 ] Department of Prosthodontics Oral Bioengineering and Regenerative Medicine Lab Shanghai Key Laboratory of Stomatology Ninth People's Hospital affiliated to Shanghai JiaoTong University School of Medicine 639 Zhizaoju Road Shanghai 200011 P. R. China
                [ 4 ] Oral and Maxillofacial Surgery Ninth People's Hospital affiliated to Shanghai JiaoTong University School of Medicine 639 Zhizaoju Road Shanghai 200011 P. R. China
                Author notes
                Author information
                http://orcid.org/0000-0002-5986-591X
                Article
                ADVS437
                10.1002/advs.201700401
                5737106
                29270348
                cf530fcd-ba30-4154-9eb7-2f31da626e16
                © 2017 The Authors. Published by WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim

                This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

                History
                : 19 July 2017
                : 31 August 2017
                Page count
                Figures: 6, Tables: 0, Pages: 9, Words: 5562
                Funding
                Funded by: National Key Research and Development Program of China
                Award ID: 2016YFB0700803
                Funded by: National Natural Science Foundation of China
                Award ID: 31370963
                Award ID: 81430012
                Funded by: Key Research Program of Frontier Sciences, CAS
                Award ID: QYZDB‐SSW‐SYS027
                Funded by: Science and Technology Commission of Shanghai Municipality
                Award ID: 17441903700
                Award ID: 16DZ2260603
                Award ID: 15XD1503900
                Categories
                Full Paper
                Full Papers
                Custom metadata
                2.0
                advs437
                December 2017
                Converter:WILEY_ML3GV2_TO_NLMPMC version:5.2.8 mode:remove_FC converted:20.12.2017

                biomimetic materials,cell delivery,lotus root‐like biomaterials,tissue regeneration

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