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      A brain serine/threonine protein kinase activated by Cdc42 and Rac1.

      1 , , , ,
      Nature
      Springer Science and Business Media LLC

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          Abstract

          A new brain serine/threonine protein kinase may be a target for the p21ras-related proteins Cdc42 and Rac1. The kinase sequence is related to that of the yeast protein STE20, implicated in pheromone-response pathways. The kinase complexes specifically with activated (GTP-bound) p21, inhibiting p21 GTPase activity and leading to kinase autophosphorylation and activation. Autophosphorylated kinase has a decreased affinity for Cdc42/Rac, freeing the p21 for further stimulatory activities or downregulation by GTPase-activating proteins. This bimolecular interaction provides a model for studying p21 regulation of mammalian phosphorylation signalling pathways.

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          Author and article information

          Journal
          Nature
          Nature
          Springer Science and Business Media LLC
          0028-0836
          0028-0836
          Jan 06 1994
          : 367
          : 6458
          Affiliations
          [1 ] Institute of Molecular & Cell Biology, National University of Singapore, Kent Ridge.
          Article
          10.1038/367040a0
          8107774
          cf614c2f-ddb5-4365-a2cb-99a8c822ec8a

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