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      Comparison of the Osteogenic Potential of Mineral Trioxide Aggregate and Endosequence Root Repair Material in a 3-dimensional Culture System.

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          Abstract

          The ability to promote osteoblast differentiation is a desirable property of root-end filling materials. Several in vitro studies compare the cytotoxicity and physical properties between mineral trioxide aggregate (MTA) and Endosequence root repair material (ERRM), but not their osteogenic potential. Three-dimensional cultures allow cells to better maintain their physiological morphology and better resemble in vivo cellular response than 2-dimensional cultures. Here we examined the osteogenic potential of MTA and ERRM by using a commercially available 3-dimensional Alvetex scaffold.

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          Author and article information

          Journal
          J Endod
          Journal of endodontics
          Elsevier BV
          1878-3554
          0099-2399
          May 2016
          : 42
          : 5
          Affiliations
          [1 ] Department of Oral Health and Diagnostic Sciences, School of Dental Medicine, University of Connecticut Health Center, Farmington, Connecticut.
          [2 ] Department of Chemical, Materials and Biomolecular Engineering, School of Engineering, University of Connecticut, Storrs, Connecticut.
          [3 ] Department of Craniofacial Sciences, School of Dental Medicine, University of Connecticut Health Center, Farmington, Connecticut.
          [4 ] Department of Oral Health and Diagnostic Sciences, School of Dental Medicine, University of Connecticut Health Center, Farmington, Connecticut. Electronic address: ipchen@uchc.edu.
          Article
          S0099-2399(16)00122-9
          10.1016/j.joen.2016.02.001
          26994596
          cf6b9dc0-332f-41c2-a199-25b970f30ecf
          History

          3-dimensional culture,Alvetex,Endosequence root repair material,mineral trioxide aggregate,osteoblast differentiation

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