Endocytosis unplugged: multiple ways to enter the cell

Abstract

Endocytosis occurs at the cell surface and involves internalization of the plasma membrane (PM) along with its constituent membrane proteins and lipids. Endocytosis is involved in sampling of the extracellular milieu and also serves to regulate various processes initiated at the cell surface. These include nutrient uptake, signaling from cell-surface receptors, and many other processes essential for cell and tissue functioning in metazoans. It is also central to the maintenance of PM lipid and protein homeostasis. There are multiple means of internalization that operate concurrently, at the cell surface. With advancement in high-resolution visualization techniques, it is now possible to track multiple endocytic cargo at the same time, revealing a remarkable diversity of endocytic processes in a single cell. A combination of live cell imaging and efficient genetic manipulations has also aided in understanding the functional hierarchy of molecular players in these mechanisms of internalization. Here we provide an account of various endocytic routes, their mechanisms of operation and occurrence across phyla.

Contributors

Satyajit Mayor: [phone] , [phone] , [e-mail]

Journal

Journal ID (nlm-ta): Cell Res

Journal ID (iso-abbrev): Cell Res

Title: Cell Research

Publisher: Nature Publishing Group UK (London )

ISSN (Print): 1001-0602

ISSN (Electronic): 1748-7838

Publication date (Electronic): 2 February 2010

Publication date (Print): March 2010

Volume: 20

Issue: 3

Pages: 256-275

Affiliations

[1 ]GRID grid.22401.35, ISNI 0000 0004 0502 9283, National Centre for Biological Science (TIFR), ; Bellary Road, Bangalore, 560 065 Karnataka India

[2 ]GRID grid.137628.9, ISNI 0000 0004 1936 8753, Present Address: current address: Molecular Pathogenesis, Marty and Helen Kimmel Center for Biology and Medicine of the Skirball Institute for Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, ; ,

Article

Publisher ID: BFcr201019

DOI: 10.1038/cr.2010.19

PMC ID: 7091825

PubMed ID: 20125123

SO-VID: cf7922b7-8ad0-44de-8724-34bca988952f

Copyright statement: © Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences 2010

License:

This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.

Categories

Subject: Article

Custom metadata

issue-copyright-statement © IBCB, SIBS, CAS 2010