Antiviral, Antibacterial, Antifungal, and Cytotoxic Silver(I) BioMOF Assembled from 1,3,5-Triaza-7-Phoshaadamantane and Pyromellitic Acid

Abstract

The present study reports the synthesis, characterization, and crystal structure of a novel bioactive metal-organic framework, [Ag ₄( µ-PTA) ₂( µ ₃-PTA) ₂( µ ₄-pma)(H ₂O) ₂] _n·6nH ₂O (bioMOF 1), which was assembled from silver(I) oxide, 1,3,5-triaza-7-phosphaadamantane (PTA), and pyromellitic acid (H ₄pma). This product was isolated as a stable microcrystalline solid and characterized by standard methods, including elemental analysis, ¹H and ³¹P{ ¹H} NMR and FTIR spectroscopy, and single crystal X-ray diffraction. The crystal structure of 1 disclosed a very complex ribbon-pillared 3D metal-organic framework driven by three different types of bridging ligands ( µ-PTA, µ ₃-PTA, and µ ₄-pma ⁴⁻). Various bioactivity characteristics of bioMOF 1 were investigated, revealing that this compound acts as a potent antimicrobial against pathogenic strains of standard Gram-negative ( Escherichia coli, Pseudomonas aeruginosa) and Gram-positive ( Staphylococcus aureus) bacteria, as well as a yeast ( Candida albicans). Further, 1 showed significant antiviral activity against human adenovirus 36 (HAdV-36). Finally, bioMOF 1 revealed high cytotoxicity toward an abnormal epithelioid cervix carcinoma (HeLa) cell line with low toxicity toward a normal human dermal fibroblast (NHDF) cell line. This study not only broadens the family of PTA-based coordination polymers but also highlights their promising multifaceted bioactivity.