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      Furin promotes epithelial-mesenchymal transition in pancreatic cancer cells via Hippo-YAP pathway.

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          Abstract

          Furin, a well-characterized proprotein convertase, plays an important role in many diseases and links to tumor metastasis. However, the role of furin in pancreatic cancer progression remains to be elucidated. In the present study, we found that furin promotes the growth and the epithelial-mesenchymal transition (EMT) of pancreatic cancer cells. First, we found that furin knockdown significantly inhibited proliferation, invasion and migration in BxPC3 and SW1990 cells, while furin overexpression promoted the above behavior in PANC1 and PaTu8988 cells. Further evidence revealed that furin knockdown resulted in the upregulation of E-cadherin (epithelial marker), and the downregulation of N-cadherin and Vimentin (mesenchymal markers) in BxPC3 and SW1990 cells, whereas furin overexpression remarkably led to the opposite effects in PANC1 and PaTu8988 cells. Furthermore, our data showed that Furin knockdown, furin inhibitor D6R or overexpression significantly affected YAP phosphoration level and total YAP protein level, indicating that furin was involved in Hippo-YAP pathway. It is suggested that furin promotes epithelial-mesenchymal transition in pancreatic cancer cells probably via Hippo-YAP pathway and may be a potential target for anti-pancreatic cancer.

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          Author and article information

          Journal
          Int. J. Oncol.
          International journal of oncology
          Spandidos Publications
          1791-2423
          1019-6439
          Apr 2017
          : 50
          : 4
          Affiliations
          [1 ] Department of Gastroenterology, Affiliated Hospital of Jiangsu University, Jiangsu University, Zhenjiang, Jiangsu, P.R. China.
          [2 ] Department of Ultrasound Diagnosis, Affiliated Hospital of Jiangsu University, Jiangsu University, Zhenjiang, Jiangsu, P.R. China.
          [3 ] Department of Cell Biology, School of Medicine, Jiangsu University, Zhenjiang, Jiangsu, P.R. China.
          Article
          10.3892/ijo.2017.3896
          28259973
          cf867271-d3b7-4ef9-8147-4db7b47899f9
          History

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