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      Are mono-exponential fits to a few echoes sufficient to determine T2 relaxation for in vivo human brain?

      1 , ,
      Magnetic resonance in medicine

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          Abstract

          T2 relaxation decay curves from in vivo human brain tissue are rarely mono-exponential. Partial volume averaging further reduces the chance of mono-exponential decay. Moreover, the parameters derived from few-echo mono-exponential fits change with the measurement echo times and have the largest possible variance. In this note, multi-exponential fits to 32-echo relaxation decay curves from in vivo human brain are used to design simulations (where the truth is known) to demonstrate the pitfalls of few-echo mono-exponential interpretations.

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          Author and article information

          Journal
          Magn Reson Med
          Magnetic resonance in medicine
          0740-3194
          0740-3194
          Jun 1999
          : 41
          : 6
          Affiliations
          [1 ] Department of Radiology, University of British Columbia, Vancouver, Canada.
          Article
          10.1002/(SICI)1522-2594(199906)41:6<1255::AID-MRM23>3.0.CO;2-I
          10.1002/(SICI)1522-2594(199906)41:6<1255::AID-MRM23>3.0.CO;2-I
          10371459
          cf9565dc-a822-4e85-b41e-f20d8c4d1002
          History

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