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      Endoscopic and Molecular Characterization of Colorectal Sessile Serrated Adenoma/polyps with Cytological Dysplasia.

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          Abstract

          Sessile serrated adenoma/polyps (SSA/Ps), which are precursor lesions of colorectal cancer (CRC) with BRAF mutation and the CpG island methylator phenotype (CIMP), develop cytological dysplasia (CD) during the progression of colorectal tumorigenesis. In the present study, we aimed to clarify the endoscopic and molecular signatures of SSA/Ps, with and without CD.

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          Author and article information

          Journal
          Gastrointest. Endosc.
          Gastrointestinal endoscopy
          Elsevier BV
          1097-6779
          0016-5107
          May 10 2017
          Affiliations
          [1 ] Department of Digestive Disease Center, Akita Red Cross Hospital, Akita, Japan.
          [2 ] Department of Gastroenterology and Hepatology, Sapporo Medical University School of Medicine, Sapporo, Japan.
          [3 ] Department of Gastroenterology and Hepatology, Sapporo Medical University School of Medicine, Sapporo, Japan; Department of Molecular Biology, Sapporo Medical University School of Medicine, Sapporo, Japan.
          [4 ] Department of Molecular Biology, Sapporo Medical University School of Medicine, Sapporo, Japan.
          [5 ] Department of Molecular Diagnostic Pathology, Iwate Medical University, Morioka, Japan.
          [6 ] Department of Molecular Biology, Sapporo Medical University School of Medicine, Sapporo, Japan. Electronic address: hsuzuki@sapmed.ac.jp.
          Article
          S0016-5107(17)31888-6
          10.1016/j.gie.2017.05.006
          28501592

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