21 November 2018
The aim of this study was to disclose the correlation between the serum levels of hypoxia-inducible factor 1 alpha (HIF-1α) and IL-19 and stable COPD.
The serum levels of HIF-1α and IL-19 were tested by ELISA. The relationships between their levels and clinical parameters of stable COPD patients were analyzed by linear regression methods.
Patients with stable COPD showed higher serum levels of HIF-1α and IL-19 compared with healthy control group ( P<0.001), and serum levels of HIF-1α and IL-19 had a positive linear correlation ( P<0.05). In stable COPD patients, increased serum levels of HIF-1α and IL-19 were positively correlated with the GOLD grading ( P<0.005), modified British Medical Research Council (mMRC) score ( P<0.05), and medical history ( P<0.05) but negatively related to the pulmonary function ( P<0.05). The serum level of HIF-1α ( P<0.05) was affected by the patient’s FEV 1/FVC value and COPD grading, and the serum level of IL-19 was associated with the mMRC scores and the serum level of HIF-1α ( P<0.05).