Blog
About

7
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      Preparation and characterization of 45S5 bioactive glass-based scaffolds loaded with PHBV microspheres with daidzein release function.

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) microsphere loaded 45S5 bioactive glass (BG) based scaffolds with drug releasing capability have been developed. PHBV microspheres with a mean particle size 4 ± 2 μm loaded with daidzein were obtained by oil-in-water single emulsion solvent evaporation method and applied to the surface of BG scaffolds by dip coating technique. The morphology, in vitro bioactivity in simulated body fluid (SBF), mechanical properties and drug release kinetics of microsphere loaded scaffolds were studied. The microspheres were shown to be homogeneously dispersed on the scaffold surfaces. It was confirmed that hydroxyapatite crystals homogeneously grew not only on the surface of the scaffold but also on the surface of the microspheres within 3 days of immersion in SBF. The daidzein release from the microsphere loaded scaffolds lasted almost 1 month and was determined to be diffusion controlled. The microsphere loaded BG scaffolds with daidzein releasing capability obtained in this study are a candidate for bone tissue engineering. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 1765-1774, 2017.

          Related collections

          Author and article information

          Journal
          J Biomed Mater Res A
          Journal of biomedical materials research. Part A
          Wiley-Blackwell
          1552-4965
          1549-3296
          Jun 2017
          : 105
          : 6
          Affiliations
          [1 ] Instituto de Investigación en Metalúrgia y Materiales, Universidad Michoacana de San Nicolás de Hidalgo, Morelia, 58030, México.
          [2 ] Department of Materials Science and Engineering, University of Erlangen-Nuremberg, Institute of Biomaterials, Erlangen, 91058, Germany.
          [3 ] Department of Materials Science and Engineering, University of Erlangen-Nuremberg, Institute of Polymer Materials, Erlangen, 91058, Germany.
          [4 ] Department of Hand-, Plastic and Reconstructive Surgery, Burn Center, Department of Hand- and Plastic Surgery of Heidelberg University, BG Trauma Center Ludwigshafen, Germany.
          [5 ] Department of Plastic Surgery of Heidelberg University, BG Trauma Center Ludwigshafen, Ludwigshafen, 67071, Germany.
          Article
          10.1002/jbm.a.36046
          28241393

          Comments

          Comment on this article