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      Research review on the pharmacological effects of astragaloside IV.

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          Abstract

          Astragalus membranaceus Bunge has been used to treat numerous diseases for thousands of years. As the main active substance of Astragalus membranaceus Bunge, astragaloside IV (AS-IV) also demonstrates the potent protective effect on focal cerebral ischemia/reperfusion, cardiovascular disease, pulmonary disease, liver fibrosis, and diabetic nephropathy. Based on studies published during the past several decades, the current state of AS-IV research and the pharmacological effects are detailed, elucidated, and summarized. This review systematically summarizes the pharmacological effects, metabolism mechanism, and the toxicity of AS-IV. AS-IV has multiple pharmacologic effects, including anti-inflammatory, antifibrotic, antioxidative stress, anti-asthma, antidiabetes, immunoregulation, and cardioprotective effect via numerous signaling pathways. According to the existing studies and clinical practices, AS-IV possesses potential for broad application in many diseases.

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          Author and article information

          Journal
          Fundam Clin Pharmacol
          Fundamental & clinical pharmacology
          Wiley-Blackwell
          1472-8206
          0767-3981
          Feb 2017
          : 31
          : 1
          Affiliations
          [1 ] College of Animal Science, Anhui Science and Technology University, Chuzhou, China.
          [2 ] Engineering Research Center of Chinese Traditional Veterinary Medicine, Beijing, China.
          Article
          10.1111/fcp.12232
          27567103
          cfb8e203-71e4-4f1b-8d5f-5df6f81c146d
          History

          astragaloside IV,metabolism,pharmacological effect,toxicity

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