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      Erythrocyte-Platelet Hybrid Membrane Coating for Enhanced Nanoparticle Functionalization

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          Abstract

          <p id="P1">Biomimetic dual membrane-functionalized nanoparticles, incorporating the natural properties of two different cell types, are fabricated by a facile process employing fused cell membranes. The resulting hybrid cell membrane-coated nanoparticles retain protein markers from each source cell and combine the unique functions of both. The reported approach opens the door for the fabrication of biocompatible nanocarriers with increasingly complex functionality. </p><p id="P2"> <div class="figure-container so-text-align-c"> <img alt="" class="figure" src="/document_file/48096f33-b534-4cd0-bd79-48ebb4e53b17/PubMedCentral/image/nihms863657u1.jpg"/> </div> </p>

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          Most cited references25

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          Cancer Cell Membrane-Coated Nanoparticles for Anticancer Vaccination and Drug Delivery

          Cell-derived nanoparticles have been garnering increased attention due to their ability to mimic many of the natural properties displayed by their source cells. This top-down engineering approach can be applied toward the development of novel therapeutic strategies owing to the unique interactions enabled through the retention of complex antigenic information. Herein, we report on the biological functionalization of polymeric nanoparticles with a layer of membrane coating derived from cancer cells. The resulting core–shell nanostructures, which carry the full array of cancer cell membrane antigens, offer a robust platform with applicability toward multiple modes of anticancer therapy. We demonstrate that by coupling the particles with an immunological adjuvant, the resulting formulation can be used to promote a tumor-specific immune response for use in vaccine applications. Moreover, we show that by taking advantage of the inherent homotypic binding phenomenon frequently observed among tumor cells the membrane functionalization allows for a unique cancer targeting strategy that can be utilized for drug delivery applications.
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            Nanoparticle delivery of cancer drugs.

            Nanomedicine, the application of nanotechnology to medicine, enabled the development of nanoparticle therapeutic carriers. These drug carriers are passively targeted to tumors through the enhanced permeability and retention effect, so they are ideally suited for the delivery of chemotherapeutics in cancer treatment. Indeed, advances in nanomedicine have rapidly translated into clinical practice. To date, there are five clinically approved nanoparticle chemotherapeutics for cancer and many more under clinical investigation. In this review, we discuss the various nanoparticle drug delivery platforms and the important concepts involved in nanoparticle drug delivery. We also review the clinical data on the approved nanoparticle therapeutics as well as the nanotherapeutics under clinical investigation.
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              Nanoparticle and targeted systems for cancer therapy.

              This review explores recent work directed towards more targeted treatment of cancer, whether through more specific anti-cancer agents or through methods of delivery. These areas include delivery by avoiding the reticuloendothelial system, utilizing the enhanced permeability and retention effect and tumor-specific targeting. Treatment opportunities using antibody-targeted therapies are summarized. The ability to treat cancer by targeting delivery through angiogenesis is also discussed and antiangiogenic drugs in clinical trials are presented. Delivery methods that specifically use nanoparticles are also highlighted, including both degradable and nondegradable polymers.
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                Author and article information

                Journal
                Advanced Materials
                Adv. Mater.
                Wiley-Blackwell
                09359648
                April 2017
                April 15 2017
                : 29
                : 16
                : 1606209
                Article
                10.1002/adma.201606209
                5469720
                28199033
                cfc80a0d-22f1-4d60-bf0a-9f686dd7475b
                © 2017

                http://doi.wiley.com/10.1002/tdm_license_1

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