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      • Record: found
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      Scribble at the crossroads

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      Author(s): 1 ,
      Publication date (Electronic):
      Journal: Journal of Biology
      Publisher: BioMed Central

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          Abstract

          Although proteins involved in determining apical-basal cell polarity have been directly linked to tumorigenesis, their precise roles in this process remain unclear. A recent report in BMC Biology clarifies the signaling pathways that control cell polarity, proliferation and apoptosis downstream of the tumor suppressor and apical-basal polarity determinant Scribble.

          See research article http://www.biomedcentral.com/1741-7007/7/62.

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          Most cited references14

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          Epithelial polarity and proliferation control: links from the Drosophila neoplastic tumor suppressors.

          David Bilder (2004)
          Mammalian epithelial tumors lose polarity as they progress toward malignancy, but whether polarity loss might causally contribute to cancer has remained unclear. In Drosophila, mutations in the "neoplastic tumor suppressor genes" (nTSGs) scribble, discs-large, and lethal giant larvae disrupt polarity of epithelia and neuroblasts, and simultaneously induce extensive overproliferation of these cells, which exhibit malignant-like characteristics. Herein I review what is known about the role of the fly nTSGs in controlling cell polarity and cell proliferation. Incorporating data from mammalian studies, I consider how polarity and proliferation can be coupled, and how disruption of polarity could promote cancer.
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            Deregulation of scribble promotes mammary tumorigenesis and reveals a role for cell polarity in carcinoma.

            Lixing Zhan, Avi Rosenberg, Kenneth Bergami … (2008)
            Loss of cell polarity proteins such as Scribble induces neoplasia in Drosophila by promoting uncontrolled proliferation. In mammals, the role that polarity proteins play during tumorigenesis is not well understood. Here, we demonstrate that depletion of Scribble in mammary epithelia disrupts cell polarity, blocks three-dimensional morphogenesis, inhibits apoptosis, and induces dysplasia in vivo that progress to tumors after long latency. Loss of Scribble cooperates with oncogenes such as c-myc to transform epithelial cells and induce tumors in vivo by blocking activation of an apoptosis pathway. Like depletion, mislocalization of Scribble from cell-cell junction was sufficient to promote cell transformation. Interestingly, spontaneous mammary tumors in mice and humans possess both downregulated and mislocalized Scribble. Thus, we demonstrate that scribble inhibits breast cancer formation and that deregulation of polarity pathways promotes dysplastic and neoplastic growth in mammals by disrupting morphogenesis and inhibiting cell death.
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              Cell polarity in development and cancer.

              Inke Näthke, Andreas Wodarz (2007)
              The development of cancer is a multistep process in which the DNA of a single cell accumulates mutations in genes that control essential cellular processes. Loss of cell-cell adhesion and cell polarity is commonly observed in advanced tumours and correlates well with their invasion into adjacent tissues and the formation of metastases. Growing evidence indicates that loss of cell-cell adhesion and cell polarity may also be important in early stages of cancer. The strongest hints in this direction come from studies on tumour suppressor genes in the fruitfly Drosophila melanogaster, which have revealed their importance in the control of apical-basal cell polarity.
              Article 0 comments Cited 91 times – based on 0 reviews     Review now
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                Author and article information

                Journal
                Journal ID (nlm-ta): J Biol
                Title: Journal of Biology
                Publisher: BioMed Central
                ISSN (Print): 1478-5854
                ISSN (Electronic): 1475-4924
                Publication date (Print): 2009
                Publication date (Electronic): 29 December 2009
                Volume: 8
                Issue: 12
                Page: 104
                Affiliations
                [1 ]Institut Pasteur, Cell Polarity and Migration Group and CNRS URA 2582, 25 rue du Dr Roux, 75724 Paris cedex 15, France
                Article
                Publisher ID: jbiol190
                DOI: 10.1186/jbiol190
                PMC ID: 2804276
                PubMed ID: 20053305
                SO-VID: cfd72662-fc77-404e-ba8a-48dddd0333e8
                Copyright © Copyright ©2009 BioMed Central Ltd
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                Subject: Minireview

                ScienceOpen disciplines: Life sciences
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                ScienceOpen disciplines: Life sciences

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