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First identification of Pseudomonas aeruginosa isolates producing a KPC-type carbapenem-hydrolyzing beta-lactamase.

Author(s): Virginia Quinn, José Ramon R A López, J Kattan, M. V. VILLEGAS, , Juan A. Correa, Karen Lolans

Publication date: 2007-03-31

Journal: Antimicrobial Agents and Chemotherapy

Keywords: Carbapenems, metabolism, pharmacology, Drug Resistance, Bacterial, genetics, Hydrolysis, Microbial Sensitivity Tests, Pseudomonas aeruginosa, enzymology, beta-Lactamases

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Abstract

In Medellin, Colombia, three Pseudomonas aeruginosa isolates with high-level carbapenem resistance (MIC>or=256 microg/ml) and an isolate of Citrobacter freundii with reduced susceptibility to imipenem produced the plasmid-mediated class A carbapenemase KPC-2. This is the first report of a KPC-type beta-lactamase identified outside of the family Enterobacteriaceae.

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PubMed ID:: 17261621

PMC ID:: 1855450

DOI:: 10.1128/AAC.01405-06

ScienceOpen disciplines: Chemistry

Keywords: Carbapenems,metabolism,pharmacology,Drug Resistance, Bacterial,genetics,Hydrolysis,Microbial Sensitivity Tests,Pseudomonas aeruginosa,enzymology,beta-Lactamases

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ScienceOpen disciplines: Chemistry

Keywords: Carbapenems, metabolism, pharmacology, Drug Resistance, Bacterial, genetics, Hydrolysis, Microbial Sensitivity Tests, Pseudomonas aeruginosa, enzymology, beta-Lactamases

First identification of Pseudomonas aeruginosa isolates producing a KPC-type carbapenem-hydrolyzing beta-lactamase.

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