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      Radial peripapillary capillary density in superior segmental optic hypoplasia measured with OCT angiography

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          Abstract

          Background

          To investigate the diagnostic power of radial peripapillary capillary (RPC) density, measured with optical coherence tomography angiography (OCT-A), in patients with superior segmental optic hypoplasia (SSOH).

          Methods

          Forty subjects with SSOH and 40 age- and axial length-matched control subjects were retrospectively registered for this study. SSOH was defined as intraocular pressure less than 21 mmHg with the presence of two of the following: superior rim thinning, superior entrance of the central retinal artery, scleral halo, and pale optic disc; as well as non-progressive visual field loss. RPC density was measured with swept-source OCT-A (Triton, Topcon) overall, in the quadrants, and in the 12 clock-wise sectors. Changes in RPC density were also compared in SSOH patients and age-matched patients with mild- or moderate-stage of glaucoma. RPC density was compared in pairs of groups with Welch’s t-test. Diagnostic power was assessed with the area under the receiver operating characteristics curve (AUC).

          Results

          Overall cpRNFLT was significantly different in the normal (106.7 ± 9.5 μm) and SSOH (77.2 ± 13.7 μm, p <  0.001) subjects. RPC density overall and in the superior, nasal, and inferior quadrants was significantly lower in the SSOH group (all, p <  0.001), but not in the temporal ( p = 0.756) quadrant. The diagnostic power of RPC density was highest in the superior quadrant (AUC = 0.928) and the 1 o’clock sector (0.896). Comparing the SSOH and glaucoma patients showed that there were no significant differences in RPC density either overall ( p = 0.391) or in the superior quadrant ( p = 0.268), while RPC density was significantly higher in the inferior ( p = 0.005) and temporal quadrants ( p <  0.001) and lower in the nasal quadrant ( p = 0.029).

          Conclusions

          Low RPC density was found in the three non-temporal quadrants of the optic nerve head in SSOH patients, in comparison to normal subjects. Regionally, RPC density in SSOH was lower in the nasal quadrant and higher in the inferior and temporal quadrants in comparison to glaucoma patients. Measuring RPC density with OCT-A may help the diagnosis of SSOH and may improve the management of glaucoma.

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          Most cited references7

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          Ocular microcirculation measurement with laser speckle flowgraphy and optical coherence tomography angiography in glaucoma

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            A New Method of Magnification Correction for Accurately Measuring Retinal Vessel Calibers From Fundus Photographs.

            To report a semiautomated retinal vessel caliber measurement system that measures central retinal artery (vein) equivalent (CRAE [CRVE]) with individual correction for magnification errors under conditions assuming optimal focus.
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              Relationship between laser speckle flowgraphy and optical coherence tomography angiography measurements of ocular microcirculation.

              The purpose of this study was to investigate the relationship between laser speckle flowgraphy (LSFG) and optical coherence tomography angiography (OCTA) measurements of ocular microcirculation in normal and open-angle glaucoma (OAG) subjects.
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                Author and article information

                Contributors
                ntoru@oph.med.tohoku.ac.jp
                Journal
                BMC Ophthalmol
                BMC Ophthalmol
                BMC Ophthalmology
                BioMed Central (London )
                1471-2415
                24 May 2020
                24 May 2020
                2020
                : 20
                : 199
                Affiliations
                [1 ]GRID grid.69566.3a, ISNI 0000 0001 2248 6943, Department of Ophthalmology, , Tohoku University Graduate School of Medicine, ; Sendai, Japan
                [2 ]GRID grid.69566.3a, ISNI 0000 0001 2248 6943, Department of Ophthalmic Imaging and Information Analytics, , Tohoku University Graduate School of Medicine, ; Sendai, Japan
                [3 ]R&D Division, Topcon Corporation, Tokyo, Japan
                Author information
                http://orcid.org/0000-0002-5591-4155
                Article
                1453
                10.1186/s12886-020-01453-6
                7245833
                32448227
                cff64379-c1dd-4767-bcf5-61e2e46a0520
                © The Author(s) 2020

                Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver ( http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

                History
                : 31 October 2019
                : 27 April 2020
                Funding
                Funded by: JSPS KAKENHI Grants-in-Aid for Scientific Research (B)
                Award ID: T.N. 26293372
                Award Recipient :
                Funded by: JST Center for Revitalization Promotion and KAKENHI Grants-in-Aid for young scientists (B)
                Award ID: K.O. 17K16957
                Award Recipient :
                Funded by: the Public Trust Suda Memorial Fund for Glaucoma Research
                Categories
                Research Article
                Custom metadata
                © The Author(s) 2020

                Ophthalmology & Optometry
                optical coherence tomography angiography,diagnosis,radial peripapillary capillary density,superior segmental optic hypoplasia

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