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      Effects of Different Nonsteroidal Anti-Inflammatory Drugs Combined with Platelet-Rich Plasma on Inflammatory Factor Levels in Patients with Osteoarthritis

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      1 , , 1 , 2 , 3
      Journal of Healthcare Engineering
      Hindawi

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          Abstract

          Objective

          To investigate the effects of different nonsteroidal anti-inflammatory drugs combined with platelet-rich plasma on inflammatory factor levels in patients with osteoarthritis.

          Methods

          The clinic data of 120 patients with osteoarthritis who were treated in our hospital (June 2019-June 2021) were retrospectively reviewed. All the patients were given platelet-rich plasma. According to the different nonsteroidal anti-inflammatory drugs the patients received, they were equalized into diclofenac sodium group, celecoxib group, and iguratimod group, with 40 cases in each group. After treatment, the patients' clinical efficacy was compared and analyzed.

          Results

          After treatment, the pain degrees of the patients in the three groups were gradually reduced. After 4 weeks and 8 weeks of treatment, the statistical differences in the scores of Visual Analogue Scale (VAS) were found among the three groups. Specifically, compared with the other two groups, the iguratimod group had remarkably lower VAS scores ( P < 0.05) and the celecoxib group had signally lower VAS scores compared with the diclofenac sodium group ( P < 0.05). After treatment, the inflammatory factor levels of interleukin-6 (IL-6), tumor necrosis factor- α (TNF- α), and high-sensitivity C-reactive protein (hs-CRP) in the diclofenac sodium group were observably higher compared with the celecoxib group ( P < 0.05), and the inflammatory factor levels in the celecoxib group were remarkably higher compared with the iguratimod group ( P < 0.05). Before treatment, no notable difference in the Lysholm scores was found among the three groups, and the patients' knee joint function was gradually improved after treatment. To be specific, after 4 and 8 weeks of treatment, the iguratimod group had observably higher Lysholm scores compared with the other two groups ( P < 0.05), and the celecoxib group had signally higher Lysholm scores compared with the diclofenac sodium group ( P < 0.05). The iguratimod group got markedly lower Western Ontario and McMaster Universities (WOMAC) score compared with the celecoxib group ( P < 0.05); Compared with the diclofenac sodium group, the celecoxib group got remarkably lower WOMAC score ( P < 0.05). During treatment, few patients suffered from mild gastrointestinal discomfort and hepatic dysfunction in the three groups, and no other severe adverse reactions were found. No statistical difference in the total incidence of adverse reactions among the three groups was observed ( P > 0.05).

          Conclusion

          The combination of nonsteroidal anti-inflammatory drugs with platelet-rich plasma can further reduce the inflammatory reactions of the patients with osteoarthritis and improve their knee joint function. Significantly, the iguratimod, with high safety, has observably better effects on inhibiting inflammatory factors and improving knee joint function compared with diclofenac sodium and celecoxib.

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          Most cited references24

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          Platelet-Rich Plasma for the Management of Hip and Knee Osteoarthritis.

          Knee and hip osteoarthritis (OA) are major public health problems worldwide causing pain, disability and impaired quality of life. This narrative paper discusses platelet-rich plasma (PRP) as a treatment for hip and knee OA, with a focus on evidence from randomised controlled trials (RCTs).
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            Is Open Access

            Meta-analysis Comparing Platelet-Rich Plasma vs Hyaluronic Acid Injection in Patients with Knee Osteoarthritis

            As a minimally invasive treatment option, intra-articular injection of platelet-rich plasma (PRP) has been widely used in clinical therapy. Our meta-analysis showed that PRP injections constitute an effective and safe alternative treatment for long-term pain relief and functional improvement in patients with knee osteoarthritis (KOA). The optimal dosage, timing intervals and frequency of injections and the ideal treatment for different stages of KOA remain areas of concern for future investigation future.
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              • Record: found
              • Abstract: not found
              • Article: not found

              Mechanistic pain profiling as a tool to predict the efficacy of 3-week nonsteroidal anti-inflammatory drugs plus paracetamol in patients with painful knee osteoarthritis

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                Author and article information

                Contributors
                Journal
                J Healthc Eng
                J Healthc Eng
                JHE
                Journal of Healthcare Engineering
                Hindawi
                2040-2295
                2040-2309
                2022
                31 March 2022
                : 2022
                : 1979892
                Affiliations
                1Department of Sports Medicine, Qilu Hospital of Shandong University, Qingdao 266035, Shandong, China
                2Department of Surgery of Traditional Chinese Medicine, The People's Hospital of South District of Qingdao, Qingdao 266000, Shandong, China
                3Department of Orthopedic Surgery, Haiyang Chinese Medicine Hospital, Yantai 265100, Shandong, China
                Author notes

                Academic Editor: Kalidoss Rajakani

                Author information
                https://orcid.org/0000-0002-4323-1453
                Article
                10.1155/2022/1979892
                8989576
                35399859
                d00d3e61-19cd-4c2b-8af0-770177c63da1
                Copyright © 2022 Wenxiao Jiang et al.

                This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                : 25 February 2022
                : 15 March 2022
                : 16 March 2022
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                Research Article

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