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      Journal of Pain Research (submit here)

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      Comparisons of the efficacy and recurrence of adenomyomectomy for severe uterine diffuse adenomyosis via laparotomy versus laparoscopy: a long-term result in a single institution

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          Abstract

          Purpose

          Studies have shown that adenomyomectomy can effectively treat women with adenomyosis in a short period of time. However, the long-term efficacy of adenomyomectomy has rarely been reported. The objective of this study was to determine whether laparotomy is superior to laparoscopic surgery in the long-term efficacy of double-flap method adenomyomectomy for severe diffuse adenomyosis.

          Methods

          Between March 2011 and September 2018, a total of 148 patients with severe uterine diffuse adenomyosis who underwent laparoscopic (group A, n=72) and laparotomic (group B, n=76) double-flap adenomyomectomy were recruited. Adenomyomectomy efficacy and adenomyosis recurrence after surgery between groups A and B were comparatively analyzed.

          Results

          The effective rate at 6-year follow up after surgery was higher in group B (75.0%) than that in group A (62.1%), while the 6-year cumulative recurrence rate was higher in group A (27.8%) than that in group B (17.1%), but the differences did not reach statistical significance between the two groups ( P>0.05). The recurrence rate was lower in patients who were treated with gonadotropin-releasing hormone agonist (GnRHa) plus Mirena or oral contraceptives post-surgically than that in patients who were treated with only GnRHa post-surgically in groups A (51.6% vs 9.8%, P<0.01) and B (33.3% vs 6.5%, P<0.05). Moreover, the recurrence rate of adenomyosis patients with endometriosis was higher than that of adenomyosis patients without endometriosis in group A (55.0% vs 17.3%, P<0.05) and group B (36.0% vs 7.8%, P<0.05).

          Conclusion

          The long-term outcomes of laparoscopic and laparotomic double-flap adenomyomectomy can be achieved for severe diffuse uterine adenomyosis, but laparotomy seems to have advantages over laparoscopy. Postoperative drug use may be beneficial to reduce the recurrence of adenomyosis, especially for adenomyosis with endometriosis.

          Most cited references26

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          Role of medical therapy in the management of uterine adenomyosis

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            Uterine adenomyosis and adenomyoma: the surgical approach

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              Uterus-sparing operative treatment for adenomyosis.

              To review systematically the literature on uterus-sparing surgical treatment options for adenomyosis.
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                Author and article information

                Journal
                J Pain Res
                J Pain Res
                JPR
                jpainres
                Journal of Pain Research
                Dove
                1178-7090
                27 June 2019
                2019
                : 12
                : 1917-1924
                Affiliations
                [1 ] The Department of Gynecology, Women’s Hospital, School of Medicine, Zhejiang University , Hangzhou, Zhejiang 310006, People’s Republic of China
                Author notes
                Correspondence: Xinmei ZhangThe Department of Gynecology, Women’s Hospital, School of Medicine, Zhejiang University , 1 Xueshi Road, Hangzhou, Zhejiang310006, People’s Republic of ChinaTel +86 57 187 061 501 2131Fax +86 5 718 706 1878Email zhangxinm@ 123456zju.edu.cn
                Article
                205561
                10.2147/JPR.S205561
                6603287
                31303783
                d0167e8a-b004-4a03-b5ee-174178318d15
                © 2019 Zhu et al.

                This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License ( http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms ( https://www.dovepress.com/terms.php).

                History
                : 15 February 2019
                : 24 May 2019
                Page count
                Figures: 1, Tables: 4, References: 28, Pages: 8
                Categories
                Original Research

                Anesthesiology & Pain management
                adenomyosis,adenomyomectomy,efficacy,recurrence,treatment
                Anesthesiology & Pain management
                adenomyosis, adenomyomectomy, efficacy, recurrence, treatment

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