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      Safety and immunogenicity of a chimpanzee adenovirus-vectored Ebola vaccine in healthy adults: a randomised, double-blind, placebo-controlled, dose-finding, phase 1/2a study.

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          Abstract

          The ongoing Ebola outbreak led to accelerated efforts to test vaccine candidates. On the basis of a request by WHO, we aimed to assess the safety and immunogenicity of the monovalent, recombinant, chimpanzee adenovirus type-3 vector-based Ebola Zaire vaccine (ChAd3-EBO-Z).

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          Author and article information

          Journal
          Lancet Infect Dis
          The Lancet. Infectious diseases
          1474-4457
          1473-3099
          Mar 2016
          : 16
          : 3
          Affiliations
          [1 ] Policlinique Médicale Universitaire, Lausanne, Switzerland. Electronic address: olga.de-santis@hospvd.ch.
          [2 ] Division of Immunology and Allergy, Lausanne University Hospital, Switzerland.
          [3 ] Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Basel, Switzerland.
          [4 ] Clinical Trial Unit, Lausanne University Hospital, Switzerland.
          [5 ] Policlinique Médicale Universitaire, Lausanne, Switzerland.
          [6 ] Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
          [7 ] GSK Vaccines, Rixensart, Belgium.
          [8 ] WHO, Geneva, Switzerland.
          [9 ] Policlinique Médicale Universitaire, Lausanne, Switzerland; Infectious Diseases Service, Department of Medicine, Lausanne University Hospital, Switzerland; Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Basel, Switzerland.
          Article
          S1473-3099(15)00486-7
          10.1016/S1473-3099(15)00486-7
          26725450
          d02ce126-355c-436f-8290-03b1d178b231
          Copyright © 2016 Elsevier Ltd. All rights reserved.
          History

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