For Publishers
DiscoveryMetadataPeer reviewHostingPublishing
For Researchers
JoinPublishReviewCollect
Register
Blog
About
Search
Advanced search
My ScienceOpen
Search
For Publishers
For Researchers
Blog
About
95
views
214
references
 Top references
cited by
24
    
0 reviews
 Review
0
comments
 Comment
1
recommends
+1 Recommend
2 collections
    2
    shares
      162
      similar
       All similar
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Extended-spectrum β-lactamase-producing and carbapenemase-producing Enterobacteriaceae

      review-article

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Antimicrobial resistance (AMR) is a global public-health emergency, which threatens the advances made by modern medical care over the past century. The World Health Organization has recently published a global priority list of antibiotic-resistant bacteria, which includes extended-spectrum β-lactamase-producing Enterobacteriaceae and carbapenemase-producing Enterobacteriaceae. In this review, we highlight the mechanisms of resistance and the genomic epidemiology of these organisms, and the impact of AMR.

          Related collections

          Most cited references214

          • Record: found
          • Abstract: found
          • Article: found
          Is Open Access

          Global increase and geographic convergence in antibiotic consumption between 2000 and 2015

          Eili Klein, Thomas P Van Boeckel, Elena M Martinez … (2018)
          Significance Antibiotic resistance, driven by antibiotic consumption, is a growing global health threat. Our report on antibiotic use in 76 countries over 16 years provides an up-to-date comprehensive assessment of global trends in antibiotic consumption. We find that the antibiotic consumption rate in low- and middle-income countries (LMICs) has been converging to (and in some countries surpassing) levels typically observed in high-income countries. However, inequities in drug access persist, as many LMICs continue to be burdened with high rates of infectious disease-related mortality and low rates of antibiotic consumption. Our findings emphasize the need for global surveillance of antibiotic consumption to support policies to reduce antibiotic consumption and resistance while providing access to these lifesaving drugs.
          Article 0 comments Cited 875 times – based on 0 reviews     Review now
            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            Extended-Spectrum β-Lactamases: a Clinical Update

            David L. Paterson, Robert Bonomo (2005)
            Extended-spectrum β-lactamases (ESBLs) are a rapidly evolving group of β-lactamases which share the ability to hydrolyze third-generation cephalosporins and aztreonam yet are inhibited by clavulanic acid. Typically, they derive from genes for TEM-1, TEM-2, or SHV-1 by mutations that alter the amino acid configuration around the active site of these β-lactamases. This extends the spectrum of β-lactam antibiotics susceptible to hydrolysis by these enzymes. An increasing number of ESBLs not of TEM or SHV lineage have recently been described. The presence of ESBLs carries tremendous clinical significance. The ESBLs are frequently plasmid encoded. Plasmids responsible for ESBL production frequently carry genes encoding resistance to other drug classes (for example, aminoglycosides). Therefore, antibiotic options in the treatment of ESBL-producing organisms are extremely limited. Carbapenems are the treatment of choice for serious infections due to ESBL-producing organisms, yet carbapenem-resistant isolates have recently been reported. ESBL-producing organisms may appear susceptible to some extended-spectrum cephalosporins. However, treatment with such antibiotics has been associated with high failure rates. There is substantial debate as to the optimal method to prevent this occurrence. It has been proposed that cephalosporin breakpoints for the Enterobacteriaceae should be altered so that the need for ESBL detection would be obviated. At present, however, organizations such as the Clinical and Laboratory Standards Institute (formerly the National Committee for Clinical Laboratory Standards) provide guidelines for the detection of ESBLs in klebsiellae and Escherichia coli . In common to all ESBL detection methods is the general principle that the activity of extended-spectrum cephalosporins against ESBL-producing organisms will be enhanced by the presence of clavulanic acid. ESBLs represent an impressive example of the ability of gram-negative bacteria to develop new antibiotic resistance mechanisms in the face of the introduction of new antimicrobial agents.
            Article 0 comments Cited 791 times – based on 0 reviews     Review now
              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              Emergence of a new antibiotic resistance mechanism in India, Pakistan, and the UK: a molecular, biological, and epidemiological study

              Karthikeyan K Kumarasamy, Mark Toleman, Timothy R. Walsh … (2010)
              Summary Background Gram-negative Enterobacteriaceae with resistance to carbapenem conferred by New Delhi metallo-β-lactamase 1 (NDM-1) are potentially a major global health problem. We investigated the prevalence of NDM-1, in multidrug-resistant Enterobacteriaceae in India, Pakistan, and the UK. Methods Enterobacteriaceae isolates were studied from two major centres in India—Chennai (south India), Haryana (north India)—and those referred to the UK's national reference laboratory. Antibiotic susceptibilities were assessed, and the presence of the carbapenem resistance gene bla NDM-1 was established by PCR. Isolates were typed by pulsed-field gel electrophoresis of XbaI-restricted genomic DNA. Plasmids were analysed by S1 nuclease digestion and PCR typing. Case data for UK patients were reviewed for evidence of travel and recent admission to hospitals in India or Pakistan. Findings We identified 44 isolates with NDM-1 in Chennai, 26 in Haryana, 37 in the UK, and 73 in other sites in India and Pakistan. NDM-1 was mostly found among Escherichia coli (36) and Klebsiella pneumoniae (111), which were highly resistant to all antibiotics except to tigecycline and colistin. K pneumoniae isolates from Haryana were clonal but NDM-1 producers from the UK and Chennai were clonally diverse. Most isolates carried the NDM-1 gene on plasmids: those from UK and Chennai were readily transferable whereas those from Haryana were not conjugative. Many of the UK NDM-1 positive patients had travelled to India or Pakistan within the past year, or had links with these countries. Interpretation The potential of NDM-1 to be a worldwide public health problem is great, and co-ordinated international surveillance is needed. Funding European Union, Wellcome Trust, and Wyeth.
              Article 0 comments Cited 776 times – based on 0 reviews     Review now
                Bookmark
                All references

                Author and article information

                Journal
                Journal ID (nlm-ta): Microb Genom
                Journal ID (iso-abbrev): Microb Genom
                Journal ID (hwp): mgen
                Journal ID (publisher-id): mgen
                Title: Microbial Genomics
                Publisher: Microbiology Society
                ISSN (Electronic): 2057-5858
                Publication date Collection: July 2018
                Publication date (Electronic): 23 July 2018
                Publication date PMC-release: 23 July 2018
                Volume: 4
                Issue: 7
                Electronic Location Identifier: e000197
                Affiliations
                [ 1​ ]Department of Medicine, University of Cambridge, Addenbrooke's Hospital , Cambridge CB2 0QQ, UK
                [ 2​ ]Cambridge University Hospitals NHS Foundation Trust , Cambridge, UK
                [ 3​ ]Clinical Microbiology and Public Health Laboratory, Public Health England , Cambridge, UK
                Author notes
                *Correspondence: Hayley Wilson, hjb60@ 123456medschl.cam.ac.uk
                Article
                Publisher ID: mgen000197
                DOI: 10.1099/mgen.0.000197
                PMC ID: 6113871
                PubMed ID: 30035710
                SO-VID: d037c38d-6f80-4534-bdc2-d30dffa37e8e
                Copyright © © 2018 The Authors
                License:

                This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                Date received : 27 September 2017
                Date accepted : 19 June 2018
                Funding
                Funded by: Academy of Medical Sciences
                Funded by: Health Foundation
                Funded by: National Institute for Health Research
                Categories
                Subject: Mini Review
                Subject: Responses to Human Interventions: Antibiotics

                Keywords: esbl,cpe,antimicrobial resistance,gram-negative,enterobacteriaceae
                Data availability:
                Keywords: esbl, cpe, antimicrobial resistance, gram-negative, enterobacteriaceae

                Comments

                Comment on this article

                scite_

                Similar content162

                See all similar

                Cited by24

                See all cited by

                Most referenced authors3,722

                See all reference authors