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      Isolated Systolic Hypertension from a Vascular Point of View

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          Due to the results of antihypertensive intervention studies, isolated systolic hypertension (ISH) has gained new interest lately. Yet, apart from increased aortic stiffness, the specific pathophysiological features of ISH have remained largely undetermined. Therefore, we investigated the elastic properties of the vascular bed of an upper arm segment in uncomplicated ISH patients and matched normotensive controls using an electrical bioimpedance technique. Compared with the controls, the compliance of the arterial bed as a whole at normotensive blood pressure level was on the average 108.0% higher (p < 0.005) in the hypertensive patients. The blood volume of the arterial bed as a whole at operating blood pressure level and that of the larger arteries were significantly higher (40.5%, p < 0.05, and 40.5%, p < 0.01, respectively). The same held true for the venous blood volume (64.4%, p < 0.05), and for the width of the arterial compliance-pressure relation (34.6%, p < 0.01). We concluded that ISH is a separate pathophysiological entity in which all parts of a peripheral vascular bed are changed and the decreased buffering function of the aorta and large arteries is partly compensated for by an increase in small artery compliance.

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          Most cited references 4

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          1999 World Health Organization-International Society of Hypertension Guidelines for the Management of Hypertension

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            The 1984 Report of the Joint National Committee on Detection, Evaluation, and Treatment of High Blood Pressure.

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              Effects of isolated systolic hypertension and essential hypertension on large and middle-sized artery compliance.

              Systolic hypertension of the elderly is characterized by a reduction in arterial compliance. Whether and to what extent this involves arteries of various structure and size is not well known.

                Author and article information

                J Vasc Res
                Journal of Vascular Research
                S. Karger AG
                December 2000
                10 January 2001
                : 37
                : 6
                : 485-493
                Departments of aMedical Physiology, bCardiology and cInternal Medicine, University of Groningen, Groningen, The Netherlands
                54081 J Vasc Res 2000;37:485–493
                © 2000 S. Karger AG, Basel

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                Page count
                Figures: 5, Tables: 2, References: 32, Pages: 9
                Research Paper


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