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Abstract
<p class="first" id="d22583697e101">Substantial advances in enantioconvergent C(sp3)-C(sp3)
bond formation reactions have
been made in recent years through the use of transition-metal-catalyzed cross-coupling
reactions of racemic secondary alkyl electrophiles with organometallic reagents. Herein,
we report a general process for the asymmetric construction of alkyl-alkyl bonds adjacent
to heteroatoms, namely, a nickel-catalyzed enantioconvergent reductive hydroalkylation
of olefins with α-heteroatom phosphorus or sulfur alkyl electrophiles. Including the
use of readily available olefins, this reaction has considerable advantages, such
as mild reaction conditions, a broad substrate scope, and good functional group compatibility,
making it a desirable alternative to traditional electrophile-nucleophile cross-coupling
reactions.
</p>
[1
]Hefei National Laboratory for Physical Sciences at the Microscale, CAS Key Laboratory
of Urban Pollutant Conversion, Anhui Province Key Laboratory of Biomass Clean Energy,
iChEM, University of Science and Technology of China, Hefei 230026, China