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      New cytotoxic lignan glycosides from Phyllanthus glaucus.

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          Abstract

          During the process of exploring bioactive lead compounds from Phyllanthus species, two new glycosides including an arylnaphthalene lignan, diphyllin 4-O-α-L-arabinopyranosyl-(1 → 3)-α-L-arabinopyranoside (1), and a phenolic compound, 3,4,5-trimethoxybenzyl alcohol 7-O-α-L-arabinofuranosyl-(1 → 6)-β-D-glucopyranoside (2), were isolated from the methanol extract of the whole plants of Phyllanthus glaucus Wall. ex Müll. Arg. In addition, 31 known compounds, including 19 lignan derivatives (3-21), four phenylpropanoids (22-25), seven simple phenolics (26-32) and one monoterpenoid (33) were obtained. Their structures were determined on the basis of the HR-ESI-MS, 1D and 2D NMR spectroscopic analysis, and pre-column derivative/chiral HPLC analysis in case of 1 for the absolute configurations. All these compounds were obtained from P. glaucus for the first time. Moreover, the known lignan glycoside, phyllanthusmin C (5) showed in vitro cytotoxicities against HL-60, MCF-7 and SW480 cells with IC50 values of 9.2 ± 0.2, 19.2 ± 1.7 and 20.5 ± 0.9, respectively.

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          Author and article information

          Journal
          Nat. Prod. Res.
          Natural product research
          Informa UK Limited
          1478-6427
          1478-6419
          2016
          : 30
          : 4
          Affiliations
          [1 ] a State Key Laboratory of Phytochemistry & Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences , Lanhei Road 132#, Kunming 650201 , People's Republic of China.
          [2 ] b University of Chinese Academy of Sciences , Beijing 100049 , People's Republic of China.
          Article
          10.1080/14786419.2015.1023198
          25791206
          d043870c-cecc-4fc1-8575-10e81959cabc
          History

          glycoside,arylnaphthalene lignan,cytotoxicity,phenolics,Phyllanthus glaucus Wall. ex Müll. Arg

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