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      Fertility-sparing Surgery in Sertoli-Leydig Cell Tumor of the Ovary: A Case Report

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          ABSTRACT

          Sertoli-Leydig cell tumors are rare sex-cord stromal tumors. They arise from the sex cord sertoli cells and from the stroma of the genital ridge, the Leydig cells. They are generally of low-grade malignancy and rarely they can be poorly differentiated when they have a very aggressive course and poor prognosis. Majority of the tumors are characterized by androgen secretion. Most of the Sertoli-Leydig cell tumors occur in younger women less than 30 years of age, which necessitates the need for conservative management. A case of Sertoli-Leydig cell tumor of the ovary occurring in a 19-year-old girl, presenting with virilizing features is presented. She was treated with unilateral salpingo-oophorectomy and adjuvant chemotherapy.

          How to cite this article

          Prabhu TRB, Senthilkumar MPA, Palanisamy A, et al. Fertility-sparing Surgery in Sertoli-Leydig Cell Tumor of the Ovary: A Case Report. J South Asian Feder Obst Gynae 2023;15(3):352–353.

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          A clinicopathological analysis of 40 cases of ovarian Sertoli-Leydig cell tumors.

          Ting Gui, Dongyan Cao, Keng Shen … (2012)
          To evaluate the clinicopathological features of ovarian Sertoli-Leydig cell tumors (SLCTs) and to explore the reasonable therapy. A total of 40 cases of SLCTs were retrospectively reviewed. The incidence of SLCTs was 0.41%, with a median age of 28 years. All tumors were confined to one ovary. Four tumors were well differentiated, 14 were intermediately differentiated, 20 were poorly differentiated, and 2 were undefined; 2 cases had heterologous elements, and 3 had a retiform pattern. The patients were classified into 3 groups: androgen excess (25/40), estrogen excess (6/40), and no endocrine changes (9/40). The percentages of tumors >10 cm in diameter were 8.0%, 16.7% and 40.0%, respectively; the percentages of poor differentiation were 40.0%, 50.0% and 77.8%, respectively; and the percentages of tumor rupture were 20.0%, 16.7% and 66.7%, respectively. One patient underwent cystectomy, 27 underwent unilateral salpingo-oophorectomy, and 12 underwent total hysterectomy and bilateral salpingo-oophorectomy. A total of 23 patients received postoperative chemotherapy. One patient died of diabetic nephropathy, and 3 were lost to follow up. The remaining 36 were followed up from 12 to 377 (average 70.4) months. Two patients with stage Ic tumors of poor differentiation had a recurrence within 13 and 21 months, and both obtained complete remission after the second surgery and chemotherapy. The prognosis of SLCTs is good, although poorly differentiated tumors may recur. Conservative surgery is acceptable for young patients wishing to preserve fertility, and postoperative adjuvant chemotherapy and long-term follow up are recommended to those with high-risk factors. Copyright © 2012 Elsevier Inc. All rights reserved.
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            Results from a Monocentric Long-Term Analysis of 23 Patients with Ovarian Sertoli-Leydig Cell Tumors.

            Sébastien Gouy, Alexandra Arfi, Amandine Maulard … (2019)
            Sertoli-Leydig cell tumors (SLCTs) represent less than 0.5% of ovarian tumors. Because of the rarity of this tumor and its peak in frequency at around 25 years of age, this study aimed to describe SLCT management strategies.
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              Sertoli Cell Tumors of the Ovary

              Teresa Álvarez, Esther N Oliva, Robert H Young (2005)
              Article 0 comments Cited 8 times – based on 0 reviews     Review now
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                Author and article information

                Journal
                Journal ID (publisher-id): JSAFOG
                Title: Journal of South Asian Federation of Obstetrics and Gynaecology
                Abbreviated Title: JSAFOG
                Publisher: Jaypee Brothers Medical Publishers
                ISSN (Print): 0974-8938
                ISSN (Electronic): 0975-1920
                Publication date (Print): May-June 2023
                Volume: 15
                Issue: 3
                Pages: 352-353
                Affiliations
                [1–4 ]Department of Obstetrics and Gynaecology, Sri Muthukumaran Medical College Hospital and Research Institute, Chikkarayapuram, Chennai, Tamil Nadu, India
                Author notes
                T Radha Bai Prabhu, Department of Obstetrics and Gynaecology, Sri Muthukumaran Medical College Hospital and Research Institute, Chikkarayapuram, Chennai, Tamil Nadu, India, Phone: +91 9444051124, e-mail: radhaprabhu54@ 123456ymail.com
                Article
                DOI: 10.5005/jp-journals-10006-2243
                SO-VID: d045891e-b881-4bb6-9bb5-5b498ed6ef82
                Copyright © Copyright © 2023; The Author(s).
                License:

                © The Author(s). 2023 Open Access. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License ( https://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted use, distribution, and non-commercial reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver ( http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

                History
                Date received : 12 December 2022
                Date accepted : 30 January 2023
                Date: 31 July 2023
                Categories
                Subject: CASE REPORT
                Custom metadata
                file-pdf jsafog-15-352.pdf

                ScienceOpen disciplines: Obstetrics & Gynecology
                Keywords: Surgery,Surgical management,Case report,Fertility sparing,Polycystic ovarian syndrome,Prognosis,Sertoli-Leydig cell tumor,Sex cord tumor
                Data availability:
                ScienceOpen disciplines: Obstetrics & Gynecology
                Keywords: Surgery, Surgical management, Case report, Fertility sparing, Polycystic ovarian syndrome, Prognosis, Sertoli-Leydig cell tumor, Sex cord tumor

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