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      The Cross-sectional Association between Vasomotor Symptoms and Hemostatic Parameter Levels in Postmenopausal Women

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          Abstract

          Objective

          Vasomotor symptoms (VMS) may be a marker of cardiovascular risk. We aimed to evaluate the cross-sectional association of VMS presence and severity with hemostatic parameter levels measured at baseline among Women’s Health Initiative (WHI) Hormone Therapy trial postmenopausal participants.

          Methods

          This cross-sectional analysis included 2,148 postmenopausal women with measures of VMS presence and severity reported in the 4 weeks prior to WHI baseline, who were not using warfarin or hormone therapy and for whom the following baseline hemostatic parameters were measured within the WHI Cardiovascular Disease (CVD) Biomarker Case-Control Study: antithrombin, plasminogen activator inhibitor-1, protein C antigen, total and free protein S antigen, total and free tissue factor pathway inhibitor, D-dimer, normalized activated protein C sensitivity ratio (nAPCsr), and thrombin generation. Using multiple linear regression, we estimated the adjusted average difference in each hemostatic parameter associated with VMS presence and severity. A multiple comparisons corrected p-value was computed using the P-min procedure to determine statistical significance of our smallest observed p-value.

          Results

          Women were 67 years of age on average and 33% reported VMS present at baseline. There was some suggestion that VMS presence may be associated with a −0.34 adjusted difference in nAPCsr compared with no VMS (95% CI: −0.60, −0.087; p=0.009), but this association was not significant after correction for multiple comparisons (p=0.073). VMS presence or severity was not significantly associated with the other hemostatic parameters.

          Conclusions

          We found no convincing evidence that VMS presence or severity was associated with levels of hemostatic parameters among postmenopausal women.

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          Author and article information

          Journal
          9433353
          21037
          Menopause
          Menopause
          Menopause (New York, N.Y.)
          1072-3714
          1530-0374
          16 September 2016
          April 2017
          01 April 2018
          : 24
          : 4
          : 360-370
          Affiliations
          [1 ]Department of Epidemiology, University of Washington, Seattle, WA
          [2 ]Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA
          [3 ]Division of Angiology and Haemostasis, Geneva University Hospitals and Faculty of Medicine, Geneva, Switzerland
          [4 ]Department of Medicine, University of Vermont, Burlington, VT
          [5 ]Department of Obstetrics and Gynecology, University of Florida College of Medicine-Jacksonville, Jacksonville, FL
          [6 ]National Heart Lung and Blood Institute, Bethesda, MD
          [7 ]Department of Preventive Medicine, University of California San Diego, San Diego, CA
          [8 ]Department of Medicine, George Washington University, Washington, DC
          [9 ]Department of Preventive Medicine, University of Tennessee Health Science Center, Memphis, TN
          [10 ]Department of Biochemistry, Maastricht University, Maastricht, Netherlands
          [11 ]School of Nursing, University of Washington, Seattle, WA
          [12 ]Department of Family Medicine and Public Health, University of California San Diego, San Diego, CA
          [13 ]Department of Biostatistics, University of Washington, Seattle, WA
          Author notes
          Corresponding Author: Laura B. Harrington, PhD, MPH; Department of Nutrition; Harvard T.H. Chan School of Public Health; 655 Huntington Avenue, Building 2; Boston, MA, 02115; lharring@ 123456hsph.harvard.edu Telephone: 617-432-1841; Fax: 617-432-2435
          Article
          PMC5365368 PMC5365368 5365368 nihpa815196
          10.1097/GME.0000000000000777
          5365368
          27922933
          d04bdbfc-9665-4b27-996b-455b33a5d9e6
          History
          Categories
          Article

          Hemostasis,Epidemiology,Hot Flashes,Menopause
          Hemostasis, Epidemiology, Hot Flashes, Menopause

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