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      Intracellular Magnesium Predicts Functional Capacity in Patients with Coronary Artery Disease

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          To determine whether increased intracellular levels of magnesium ([Mg]<sub>i</sub>) are associated with enhanced functional capacity, we performed symptom-limited exercise treadmill testing on 42 stable coronary artery disease (CAD) patients (37 men, 5 women, mean age 68 ± 9 years). [Mg]<sub>i</sub> was found to be an independent and significant predictor of exercise duration (R = 0.31, p = 0.02) in a multivariate stepwise regression model. Patients with > normal [Mg]<sub>i</sub> of 1.23 µg/mg protein (n = 13) had a significantly greater mean functional capacity, measured in higher achieved metabolic equivalents (10.6 ± 2.5 vs. 8.9 ± 2.3, p < 0.05) and exercise duration (9.4 ± 2.3 vs. 7.9 ± 2.2 min, p < 0.05) compared to patients with [Mg]<sub>i</sub> ≤ the normal (n = 29). Thus, functional capacity is greater in stable CAD patients with higher [Mg]<sub>i</sub>, suggesting that magnesium may play a role in CAD pathophysiology, possibly via ventricular unloading.

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          Author and article information

          S. Karger AG
          December 1998
          15 October 2008
          : 90
          : 3
          : 168-172
          a Division of Cardiology, Department of Medicine, Preventive and Rehabilitative Cardiac Center, Cedars-Sinai Medical Center and UCLA School of Medicine, b Department of Endocrinology, USC Orthopedic Hospital, and USC School of Medicine, Los Angeles, Calif., USA
          6839 Cardiology 1998;90:168–172
          © 1998 S. Karger AG, Basel

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          Page count
          Figures: 2, Tables: 3, References: 16, Pages: 5
          General Cardiology


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