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      Intracellular Magnesium Predicts Functional Capacity in Patients with Coronary Artery Disease

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          Abstract

          To determine whether increased intracellular levels of magnesium ([Mg]<sub>i</sub>) are associated with enhanced functional capacity, we performed symptom-limited exercise treadmill testing on 42 stable coronary artery disease (CAD) patients (37 men, 5 women, mean age 68 ± 9 years). [Mg]<sub>i</sub> was found to be an independent and significant predictor of exercise duration (R = 0.31, p = 0.02) in a multivariate stepwise regression model. Patients with > normal [Mg]<sub>i</sub> of 1.23 µg/mg protein (n = 13) had a significantly greater mean functional capacity, measured in higher achieved metabolic equivalents (10.6 ± 2.5 vs. 8.9 ± 2.3, p < 0.05) and exercise duration (9.4 ± 2.3 vs. 7.9 ± 2.2 min, p < 0.05) compared to patients with [Mg]<sub>i</sub> ≤ the normal (n = 29). Thus, functional capacity is greater in stable CAD patients with higher [Mg]<sub>i</sub>, suggesting that magnesium may play a role in CAD pathophysiology, possibly via ventricular unloading.

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          Author and article information

          Journal
          CRD
          Cardiology
          10.1159/issn.0008-6312
          Cardiology
          S. Karger AG
          0008-6312
          1421-9751
          1998
          December 1998
          15 October 2008
          : 90
          : 3
          : 168-172
          Affiliations
          a Division of Cardiology, Department of Medicine, Preventive and Rehabilitative Cardiac Center, Cedars-Sinai Medical Center and UCLA School of Medicine, b Department of Endocrinology, USC Orthopedic Hospital, and USC School of Medicine, Los Angeles, Calif., USA
          Article
          6839 Cardiology 1998;90:168–172
          10.1159/000006839
          9892764
          © 1998 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Figures: 2, Tables: 3, References: 16, Pages: 5
          Categories
          General Cardiology

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