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      Loss of protein phosphatase 2A expression correlates with phosphorylation of DP-1 and reversal of dysplasia through differentiation in a conditional mouse model of cancer progression.

      Cancer research
      Adenocarcinoma, genetics, metabolism, pathology, Animals, Cell Cycle Proteins, Cell Differentiation, physiology, Cell Transformation, Neoplastic, Disease Models, Animal, Down-Regulation, Gene Expression Regulation, Neoplastic, Mice, Mice, Transgenic, Oncogenes, Phosphoprotein Phosphatases, biosynthesis, deficiency, pharmacology, Phosphorylation, Protein Phosphatase 2, RNA, Messenger, Salivary Gland Neoplasms, Submandibular Gland, enzymology, Transcription Factor DP1, Transcription Factors

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          Abstract

          A conditional mouse model of time-dependent dysplasia reversal demonstrated that reversal and differentiation of dysplastic salivary gland tissue at the 4-month reversible stage was characterized by the appearance of a phosphorylated slower mobility form of Differentiation Related Transcription Factor 1-polypeptide-1 that was correlated with cellular differentiation. The phosphorylated form of DP-1 was not found at the 7-month irreversible stage or in adenocarcinomas. At the 4-month reversible stage, protein phosphatase 2A expression was down-regulated coincident with loss of oncogene expression, whereas PP2A expression persisted at the 7-month irreversible stage. Results are consistent with the hypothesis that persistent PP2A expression prevented the appearance of the phosphorylated form of DP-1 required for cellular differentiation and reversal of dysplasia after loss of oncogene expression.

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