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      Normal Control of Growth Hormone Secretion

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          Abstract

          Growth hormone (GH) is secreted by the anterior pituitary gland in a pulsatile fashion under the regulation of two hypothalamic peptides: GH-releasing hormone (GHRH) stimulates GH synthesis and secretion while somatostatin inhibits GH release. Studies in rats, sheep and humans indicate that whereas GHRH is required for the initiation of GH pulses, the amplitude of GH pulses is modulated by somatostatin. In humans, these interactions result in a pattern of volleys of GH-secretory pulses with intervening periods of relative secretory quiescence. The amplitude and frequency of GH-secretory pulses are regulated by a complex array of external and internal stimuli including age, gender, menstrual cycle phase, pubertal status, nutrition, sleep, body composition and exercise. Changes in plasma concentrations of gonadal hormones, insulin and insulin-like growth factor-I likely mediate the effects of several of these factors. A greater understanding of the physiology of GH secretion will enable the development of future strategies to enhance GH secretion in GH-deficient states including the use of GH secretagogues and modification of nutrition and exercise habits.

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          Author and article information

          Journal
          HRE
          Horm Res Paediatr
          10.1159/issn.1663-2818
          Hormone Research in Paediatrics
          S. Karger AG
          978-3-8055-5924-9
          978-3-318-01776-2
          1663-2818
          1663-2826
          1993
          1993
          05 December 2008
          : 40
          : 1-3
          : 37-47
          Affiliations
          aDepartment of Medicine, University of Virginia Health Sciences Center, and bNational Science Foundation Science and Technology Center for Biological Timing, Charlottesville, Va.USA
          Article
          183766 Horm Res 1993;40:37–47
          10.1159/000183766
          8300049
          © 1993 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 11
          Categories
          Session II: Pathophysiology of GH

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