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      Adjunctive effects of laser therapy on somatosensory function and vasomotor regulation of periodontal tissues in patients with periodontitis: A randomized controlled clinical trial

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          Most cited references 2

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          Is Open Access

          Matrix Metalloproteinases in Neuropathic Pain and Migraine: Friends, Enemies, and Therapeutic Targets

          Matrix metalloproteinases (MMPs) constitute a family of zinc-dependent endopeptidases that mediate extracellular matrix turnover and associated processes, such as cell survival, growth, and differentiation. This paper discusses important functions of MMP in the normal and injured nervous system, focusing on the role played by these proteases in neurological pain syndromes, most prominently in neuropathic pain and migraine headaches. In the past decade, metalloproteinases emerged as key modulators of neuropathic pain, with MMP-9 acting as an initiator of the neuropathic cascade. Increased MMP activity was detected in migraine patients, independent of aura, in tight association with metabolic derangements. The therapeutic implications of MMP inhibition are considered in the context of neurogenic pain regulation.
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            The pulsed Nd:YAG dental laser: review of clinical applications.

             T Myers,  J D McDaniel (1991)
            Since the first demonstration of a laser in 1960, numerous applications of this unique form of energy have been developed for the manufacturing, electronic, consumer and medical industries. Recent technological innovations have permitted development of lasers appropriate for use in the dental operatory. The carbon dioxide laser has been used for soft tissue surgery; the Nd:YAG laser has both soft and hard tissue applications. Advantages of laser treatment over conventional methods include minimal cellular destruction and tissue swelling, hemostasis, increased visualization of surgical sites and reduced post-operative pain. Additionally, it is possible to perform many procedures without needing anesthesia. Soft tissue clinical applications of the Nd:YAG laser include gingivectomies, gingivoplasties, operculectomies, biopsies, incising and draining procedures, frenectomies and treatment of aphthous ulcers; hard tissue clinical applications include vaporizing decay, etching enamel and dentin, desensitizing exposed root structure and creating temporary analgesia. As both clinical experiences and scientific investigations expand, possible future applications of the dental laser may well include development of new dental adhesives and composite systems, new methods for managing caries and new endodontic treatments. With its numerous benefits, the laser is having a positive impact on patients and the dental team.
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              Author and article information

              Contributors
              Journal
              Journal of Periodontology
              J Periodontol
              Wiley
              0022-3492
              1943-3670
              October 2020
              July 11 2020
              October 2020
              : 91
              : 10
              : 1307-1317
              Affiliations
              [1 ]Jiangsu Key Laboratory of Oral Disease Affiliated Hospital of Stomatology Nanjing Medical University Nanjing China
              [2 ]Department of Periodontics Affiliated Hospital of Stomatology Nanjing Medical University Nanjing China
              [3 ]Section of Orofacial Pain and Jaw Function Department of Dentistry and Oral Health Aarhus University Aarhus Denmark
              [4 ]Department of Orofacial Pain and Jaw Function Faculty of Odontology Malmø University Malmø Sweden
              [5 ]Scandinavian Center for Orofacial Neurosciences (SCON) Aarhus Denmark
              [6 ]Center for Sensory‐Motor Interaction (SMI) Department of Health Science & Technology Aalborg University Aalborg Denmark
              Article
              10.1002/JPER.19-0562
              © 2020

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