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Multimodal imaging guided photothermal therapy using functionalized graphene nanosheets anchored with magnetic nanoparticles.
Kai Yang
1 ,
Lilei Hu ,
Xingxing Ma ,
Shuoqi Ye ,
Liang Cheng ,
Xiaoze Shi ,
Changhui Li ,
Yonggang Li ,
Zhuang Liu
Apr 10 2012
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Abstract
In this work, a nanoscale reduced graphene oxide-iron oxide nanoparticle (RGO-IONP) complex is noncovalently functionalized with polyethylene glycol (PEG), obtaining a RGO-IONP-PEG nanocomposite with excellent physiological stability, strong NIR optical absorbance, and superparamagnetic properties. Using this theranostic nanoprobe, in-vivo triple modal fluorescence, photoacoustic, and magnetic resonance imaging are carried out, uncovering high passive tumor targeting, which is further used for effective photothermal ablation of tumors in mice.