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      Spontaneous low frequency oscillations of cerebral hemodynamics and metabolism in human adults.

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          Abstract

          We investigated slow spontaneous oscillations in cerebral oxygenation in the human adult's visual cortex. The rationale was (1) to demonstrate their detectability by near infrared spectroscopy (NIRS); (2) to analyze the spectral power of as well as the phase relationship between the different NIRS parameters (oxygenated and deoxygenated hemoglobin and cytochrome-oxidase; oxy-Hb/deoxy-Hb/Cyt-ox). Also (3) influences of functional stimulation and hypercapnia on power and phase shifts were investigated. The results show that-in line with the literature-low frequency oscillations (LFO) centred around 0.1 s(-1) and even slower oscillations at about 0.04 s(-1) (very low frequency, VLFO) can be distinguished. Their respective power differs between oxy-Hb, deoxy-Hb, and Cyt-ox. Either frequency (LFO and VLFO) is altered in magnitude by functional stimulation of the cortical area examined. Also we find a change of the phase shift between the vascular parameters (oxy-Hb, tot-Hb) and the metabolic parameter (Cyt-ox) evoked by the stimulation. It is shown that hypercapnia attenuates the LFO in oxy-Hb and deoxy-Hb.

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          Author and article information

          Journal
          Neuroimage
          NeuroImage
          Elsevier BV
          1053-8119
          1053-8119
          Dec 2000
          : 12
          : 6
          Affiliations
          [1 ] Neurologische Klinik der Charité, Humboldt-Universität zu Berlin, 10098 Berlin, Germany.
          S1053-8119(00)90657-8
          10.1006/nimg.2000.0657
          11112395

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